Next Article in Journal
A Mini-Review for Cancer Immunotherapy: Molecular Understanding of PD-1/PD-L1 Pathway & Translational Blockade of Immune Checkpoints
Next Article in Special Issue
Aquaporins in the Colon as a New Therapeutic Target in Diarrhea and Constipation
Previous Article in Journal
“On-The-Spot” Arresting of Chondroitin Sulphate Proteoglycans: Implications for Ovarian Adenocarcinoma Recognition and Intervention
Previous Article in Special Issue
Expression and Distribution Pattern of Aquaporin 4, 5 and 11 in Retinas of 15 Different Species
Article Menu
Issue 7 (July) cover image

Export Article

Open AccessReview
Int. J. Mol. Sci. 2016, 17(7), 1146; doi:10.3390/ijms17071146

Progress in AQP Research and New Developments in Therapeutic Approaches to Ischemic and Hemorrhagic Stroke

1
Department of Neurosurgery, Wayne State University School of Medicine, Detroit, MI 48201, USA
2
Department of Neurology, Beijing Luhe Hospital, Capital Medical University, Beijing 101199, China
3
China-America Institute of Neuroscience, Beijing Luhe Hospital, Capital Medical University, Beijing 101199, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editor: Kenichi Ishibashi
Received: 17 June 2016 / Revised: 6 July 2016 / Accepted: 7 July 2016 / Published: 18 July 2016
(This article belongs to the Special Issue Aquaporin)
View Full-Text   |   Download PDF [923 KB, uploaded 19 July 2016]   |  

Abstract

Cerebral edema often manifests after the development of cerebrovascular disease, particularly in the case of stroke, both ischemic and hemorrhagic. Without clinical intervention, the influx of water into brain tissues leads to increased intracranial pressure, cerebral herniation, and ultimately death. Strategies to manage the development of edema constitute a major unmet therapeutic need. However, despite its major clinical significance, the mechanisms underlying cerebral water transport and edema formation remain elusive. Aquaporins (AQPs) are a class of water channel proteins which have been implicated in the regulation of water homeostasis and cerebral edema formation, and thus represent a promising target for alleviating stroke-induced cerebral edema. This review examines the significance of relevant AQPs in stroke injury and subsequently explores neuroprotective strategies aimed at modulating AQP expression, with a particular focus on AQP4, the most abundant AQP in the central nervous system. View Full-Text
Keywords: aquaporin; vasogenic edema; cytotoxic edema; ischemic stroke; hemorrhagic stroke aquaporin; vasogenic edema; cytotoxic edema; ischemic stroke; hemorrhagic stroke
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Previch, L.E.; Ma, L.; Wright, J.C.; Singh, S.; Geng, X.; Ding, Y. Progress in AQP Research and New Developments in Therapeutic Approaches to Ischemic and Hemorrhagic Stroke. Int. J. Mol. Sci. 2016, 17, 1146.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top