Advanced Glycation End-Products Enhance Lung Cancer Cell Invasion and Migration
AbstractEffects of carboxymethyllysine (CML) and pentosidine, two advanced glycation end-products (AGEs), upon invasion and migration in A549 and Calu-6 cells, two non-small cell lung cancer (NSCLC) cell lines were examined. CML or pentosidine at 1, 2, 4, 8 or 16 μmol/L were added into cells. Proliferation, invasion and migration were measured. CML or pentosidine at 4–16 μmol/L promoted invasion and migration in both cell lines, and increased the production of reactive oxygen species, tumor necrosis factor-α, interleukin-6 and transforming growth factor-β1. CML or pentosidine at 2–16 μmol/L up-regulated the protein expression of AGE receptor, p47phox, intercellular adhesion molecule-1 and fibronectin in test NSCLC cells. Matrix metalloproteinase-2 protein expression in A549 and Calu-6 cells was increased by CML or pentosidine at 4–16 μmol/L. These two AGEs at 2–16 μmol/L enhanced nuclear factor κ-B (NF-κ B) p65 protein expression and p38 phosphorylation in A549 cells. However, CML or pentosidine at 4–16 μmol/L up-regulated NF-κB p65 and p-p38 protein expression in Calu-6 cells. These findings suggest that CML and pentosidine, by promoting the invasion, migration and production of associated factors, benefit NSCLC metastasis. View Full-Text
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Hsia, T.-C.; Yin, M.-C.; Mong, M.-C. Advanced Glycation End-Products Enhance Lung Cancer Cell Invasion and Migration. Int. J. Mol. Sci. 2016, 17, 1289.
Hsia T-C, Yin M-C, Mong M-C. Advanced Glycation End-Products Enhance Lung Cancer Cell Invasion and Migration. International Journal of Molecular Sciences. 2016; 17(8):1289.Chicago/Turabian Style
Hsia, Te-Chun; Yin, Mei-Chin; Mong, Mei-Chin. 2016. "Advanced Glycation End-Products Enhance Lung Cancer Cell Invasion and Migration." Int. J. Mol. Sci. 17, no. 8: 1289.
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