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Int. J. Mol. Sci. 2015, 16(9), 22169-22189; doi:10.3390/ijms160922169

Impacts of Alternative Splicing Events on the Differentiation of Adipocytes

School of Medical Laboratory Science and Biotechnology, College of Medical Science and Technology, Taipei Medical University, 250 Wu-Hsing Street, Taipei 11031, Taiwan
Academic Editor: Charles Brennan
Received: 13 August 2015 / Revised: 7 September 2015 / Accepted: 7 September 2015 / Published: 14 September 2015
(This article belongs to the Special Issue Post-Transcriptional Gene Regulation by Ribonucleoprotein Complexes)
View Full-Text   |   Download PDF [1202 KB, uploaded 14 September 2015]   |  

Abstract

Alternative splicing was found to be a common phenomenon after the advent of whole transcriptome analyses or next generation sequencing. Over 90% of human genes were demonstrated to undergo at least one alternative splicing event. Alternative splicing is an effective mechanism to spatiotemporally expand protein diversity, which influences the cell fate and tissue development. The first focus of this review is to highlight recent studies, which demonstrated effects of alternative splicing on the differentiation of adipocytes. Moreover, use of evolving high-throughput approaches, such as transcriptome analyses (RNA sequencing), to profile adipogenic transcriptomes, is also addressed. View Full-Text
Keywords: adipogenesis; alternative splicing; splicing factor; transcriptome analysis adipogenesis; alternative splicing; splicing factor; transcriptome analysis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Lin, J.-C. Impacts of Alternative Splicing Events on the Differentiation of Adipocytes. Int. J. Mol. Sci. 2015, 16, 22169-22189.

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