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Int. J. Mol. Sci. 2015, 16(7), 16576-16592; doi:10.3390/ijms160716576

B Cells and Autoantibodies in Multiple Sclerosis

1
Department of Neurology, University Hospital Basel, Petersgraben 4 & Clinical Neuroimmunology, Hebelstrasse 20, 4031 Basel, Switzerland
2
Department of Biomedicine, University of Basel, Hebelstrasse 20, 4031 Basel, Switzerland
*
Author to whom correspondence should be addressed.
Academic Editors: Christoph Kleinschnitz and Sven Meuth
Received: 16 June 2015 / Revised: 15 July 2015 / Accepted: 15 July 2015 / Published: 21 July 2015
(This article belongs to the Special Issue Advances in Multiple Sclerosis)
View Full-Text   |   Download PDF [681 KB, uploaded 21 July 2015]

Abstract

While over the past decades T cells have been considered key players in the pathogenesis of multiple sclerosis (MS), it has only recently become evident that B cells have a major contributing role. Our understanding of the role of B cells has evolved substantially following the clinical success of B cell-targeting therapies and increasing experimental evidence for significant B cell involvement. Rather than mere antibody-producing cells, it is becoming clear that they are team players with the capacity to prime and regulate T cells, and function both as pro- and anti-inflammatory mediators. However, despite tremendous efforts, the target antigen(s) of B cells in MS have yet to be identified. The first part of this review summarizes the clinical evidence and results from animal studies pointing to the relevance of B cells in the pathogenesis of MS. The second part gives an overview of the currently known potential autoantigen targets. The third part recapitulates and critically appraises the currently available B cell-directed therapies. View Full-Text
Keywords: multiple sclerosis; neuromyelitis optica; B cells; autoantibodies; autoantigen; pathogenesis; therapy multiple sclerosis; neuromyelitis optica; B cells; autoantibodies; autoantigen; pathogenesis; therapy
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Pröbstel, A.-K.; Sanderson, N.S.R.; Derfuss, T. B Cells and Autoantibodies in Multiple Sclerosis. Int. J. Mol. Sci. 2015, 16, 16576-16592.

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