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Int. J. Mol. Sci. 2015, 16(7), 16514-16528; doi:10.3390/ijms160716514

Sleep Disorders Reduce Health-Related Quality of Life in Multiple Sclerosis (Nottingham Health Profile Data in Patients with Multiple Sclerosis)

1
Interdisciplinary Center for Sleep Medicine, Charité University Medicine Berlin, Charitéplatz 1, 10117 Berlin, Germany
2
NeuroCure Clinical Research Center, Charité University Medicine Berlin, Charitéplatz 1, 10117 Berlin, Germany
3
Department of Neurology, St. Joseph Hospital Berlin-Weissensee, 13088 Berlin, Germany
4
CRO SOSTANA GmbH and Charité University Medicine Berlin, Wildensteiner Straße 27, 10318 Berlin, Germany
5
Clinical and Experimental Multiple Sclerosis Research Center, Department of Neurology, Charité University Medicine Berlin, 10117 Berlin, Germany
*
Author to whom correspondence should be addressed.
Academic Editor: Christoph Kleinschnitz
Received: 30 May 2015 / Revised: 13 July 2015 / Accepted: 14 July 2015 / Published: 21 July 2015
(This article belongs to the Special Issue Advances in Multiple Sclerosis)
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Abstract

Quality of Life (QoL) is decreased in multiple sclerosis (MS), but studies about the impact of sleep disorders (SD) on health-related quality of Life (HRQoL) are lacking. From our original cohort, a cross-sectional polysomnographic (PSG) study in consecutive MS patients, we retrospectively analysed the previously unpublished data of the Nottingham Health Profile (NHP). Those MS patients suffering from sleep disorders (n = 49) showed significantly lower HRQoL compared to MS patients without sleep disorders (n = 17). Subsequently, we classified the patients into four subgroups: insomnia (n = 17), restless-legs syndrome, periodic limb movement disorder and SD due to leg pain (n = 24), obstructive sleep apnea (n = 8) and patients without sleep disorder (n = 17). OSA and insomnia patients showed significantly higher NHP values and decreased HRQoL not only for the sleep subscale but also for the “energy” and “emotional” area of the NHP. In addition, OSA patients also showed increased NHP values in the “physical abilities” area. Interestingly, we did not find a correlation between the objective PSG parameters and the subjective sleep items of the NHP. However, this study demonstrates that sleep disorders can reduce HRQoL in MS patients and should be considered as an important confounder in all studies investigating HRQoL in MS. View Full-Text
Keywords: restless legs syndrome; sleep disorders; multiple sclerosis; clinical neurophysiology; polysomnography; insomnia; pain; depression; health; quality of life restless legs syndrome; sleep disorders; multiple sclerosis; clinical neurophysiology; polysomnography; insomnia; pain; depression; health; quality of life
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Veauthier, C.; Gaede, G.; Radbruch, H.; Wernecke, K.-D.; Paul, F. Sleep Disorders Reduce Health-Related Quality of Life in Multiple Sclerosis (Nottingham Health Profile Data in Patients with Multiple Sclerosis). Int. J. Mol. Sci. 2015, 16, 16514-16528.

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