Next Article in Journal
8-p-Hdroxybenzoyl Tovarol Induces Paraptosis Like Cell Death and Protective Autophagy in Human Cervical Cancer HeLa Cells
Next Article in Special Issue
Human Dermal Stem/Progenitor Cell-Derived Conditioned Medium Improves Senescent Human Dermal Fibroblasts
Previous Article in Journal
Cutaneous Adverse Events Associated with Interferon-β Treatment of Multiple Sclerosis
Previous Article in Special Issue
Human Adipose-Derived Mesenchymal Progenitor Cells Engraft into Rabbit Articular Cartilage
Article Menu
Issue 7 (July) cover image

Export Article

Open AccessReview
Int. J. Mol. Sci. 2015, 16(7), 14961-14978; doi:10.3390/ijms160714961

Therapeutic Potential of Differentiated Mesenchymal Stem Cells for Treatment of Osteoarthritis

1
Catholic Kwandong University International St. Mary's Hospital, Incheon 404-834, Korea
2
Department of Integrated Omics for Biomedical Sciences, Yonsei University, 50 Yonsei-ro, Seodamun-gu, Seoul 120-759, Korea
3
Department of Biology Education, College of Education, Pusan National University, Busan 609-735, Korea
4
Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
5
Department of Molecular Physiology, College of Pharmacy, Kyungpook National University, Daegu 702-701, Korea
6
Department of Life Systems, Sookmyung Women's University, Seoul 140-742, Korea
7
Institute of Catholic Integrative Medicine, Incheon St. Mary's Hospital, the Catholic University of Korea, College of Medicine, Incheon 403-720, Korea
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editor: Wilhelm Bloch
Received: 22 April 2015 / Revised: 24 June 2015 / Accepted: 26 June 2015 / Published: 2 July 2015
(This article belongs to the Special Issue Stem Cell Activation in Adult Organism)
View Full-Text   |   Download PDF [708 KB, uploaded 2 July 2015]

Abstract

Osteoarthritis (OA) is a chronic, progressive, and irreversible degenerative joint disease. Conventional OA treatments often result in complications such as pain and limited activity. However, transplantation of mesenchymal stem cells (MSCs) has several beneficial effects such as paracrine effects, anti-inflammatory activity, and immunomodulatory capacity. In addition, MSCs can be differentiated into several cell types, including chondrocytes, osteocytes, endothelia, and adipocytes. Thus, transplantation of MSCs is a suggested therapeutic tool for treatment of OA. However, transplanted naïve MSCs can cause problems such as heterogeneous populations including differentiated MSCs and undifferentiated cells. To overcome this problem, new strategies for inducing differentiation of MSCs are needed. One possibility is the application of microRNA (miRNA) and small molecules, which regulate multiple molecular pathways and cellular processes such as differentiation. Here, we provide insight into possible strategies for cartilage regeneration by transplantation of differentiated MSCs to treat OA patients. View Full-Text
Keywords: osteoarthritis; mesenchymal stem cells; microRNA; small molecule; differentiation osteoarthritis; mesenchymal stem cells; microRNA; small molecule; differentiation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Ham, O.; Lee, C.Y.; Kim, R.; Lee, J.; Oh, S.; Lee, M.Y.; Kim, J.; Hwang, K.-C.; Maeng, L.-S.; Chang, W. Therapeutic Potential of Differentiated Mesenchymal Stem Cells for Treatment of Osteoarthritis. Int. J. Mol. Sci. 2015, 16, 14961-14978.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top