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Int. J. Mol. Sci. 2015, 16(7), 14979-14996; doi:10.3390/ijms160714979

8-p-Hdroxybenzoyl Tovarol Induces Paraptosis Like Cell Death and Protective Autophagy in Human Cervical Cancer HeLa Cells

School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China
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Academic Editor: Maurizio Battino
Received: 20 May 2015 / Revised: 16 June 2015 / Accepted: 23 June 2015 / Published: 2 July 2015
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Abstract

8-p-Hdroxybenzoyl tovarol (TAW) is a germacrane-type sesquiterpenoid that can be isolated from the roots of Ferula dissecta (Ledeb.) Ledeb. In this study, the growth inhibitory effects induced by TAW were screened on some types of tumor cells, and the mechanism was investigated on TAW-induced growth inhibition, including paraptosis and autophagy in human cervical cancer HeLa cells. TAW-induced paraptosis involved extensive cytoplasmic vacuolization in the absence of caspase activation. Additionally, TAW evoked cell paraptotic death mediated by endoplasmic reticulum (ER) stress and unfolded protein response (UPR). Autophagy induced by TAW was found to antagonize paraptosis in HeLa cells. This effect was enhanced by rapamycin and suppressed by the autophagy inhibitor, 3-methyladenine (3MA). Loss of beclin 1 (an autophagic regulator) function led to promote ER stress. Taken together, these results suggest that TAW induces paraptosis like cell death and protective autophagy in HeLa cells, which would provide a new clue for exploiting TAW as a promising agent for the treatment of cervical cancer. View Full-Text
Keywords: 8-p-hdroxybenzoyl tovarol; germacrane-type sesquiterpenoid; Ferula dissecta; HeLa cell; paraptosis; autophagy 8-p-hdroxybenzoyl tovarol; germacrane-type sesquiterpenoid; Ferula dissecta; HeLa cell; paraptosis; autophagy
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Zhang, C.; Jiang, Y.; Zhang, J.; Huang, J.; Wang, J. 8-p-Hdroxybenzoyl Tovarol Induces Paraptosis Like Cell Death and Protective Autophagy in Human Cervical Cancer HeLa Cells. Int. J. Mol. Sci. 2015, 16, 14979-14996.

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