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Int. J. Mol. Sci. 2015, 16(7), 14951-14960; doi:10.3390/ijms160714951

Cutaneous Adverse Events Associated with Interferon-β Treatment of Multiple Sclerosis

1
Klinik und Poliklinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum Würzburg, Josef-Schneider-Str. 2, 97080 Würzburg, Germany
2
Klinik für Neurologie, Caritas Krankenhaus Bad Mergentheim gGmbH, Uhlandstr. 7, 97980 Bad Mergentheim, Germany
*
Author to whom correspondence should be addressed.
Academic Editor: Christoph Kleinschnitz
Received: 19 May 2015 / Revised: 23 June 2015 / Accepted: 26 June 2015 / Published: 2 July 2015
(This article belongs to the Special Issue Advances in Multiple Sclerosis)
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Abstract

Interferons are widely used platform therapies as disease-modifying treatment of patients with multiple sclerosis. Although interferons are usually safe and well tolerated, they frequently cause dermatological side effects. Here, we present a multiple sclerosis (MS) patient treated with interferon-β who developed new-onset psoriasis. Both her MS as well as her psoriasis finally responded to treatment with fumarates. This case illustrates that interferons not only cause local but also systemic adverse events of the skin. These systemic side effects might indicate that the Th17/IL-17 axis plays a prominent role in the immunopathogenesis of this individual case and that the autoimmune process might be deteriorated by further administration of interferons. In conclusion, we think that neurologists should be aware of systemic cutaneous side effects and have a closer look on interferon-associated skin lesions. Detection of psoriasiform lesions might indicate that interferons are probably not beneficial in the individual situation. We suggest that skin lesions may serve as biomarkers to allocate MS patients to adequate disease-modifying drugs. View Full-Text
Keywords: multiple sclerosis; interferon-β; therapy; cutaneous adverse events; psoriasis multiple sclerosis; interferon-β; therapy; cutaneous adverse events; psoriasis
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Kolb-Mäurer, A.; Goebeler, M.; Mäurer, M. Cutaneous Adverse Events Associated with Interferon-β Treatment of Multiple Sclerosis. Int. J. Mol. Sci. 2015, 16, 14951-14960.

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