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Int. J. Mol. Sci. 2015, 16(5), 10578-10600; doi:10.3390/ijms160510578

Encapsulated Cellular Implants for Recombinant Protein Delivery and Therapeutic Modulation of the Immune System

1
Division of Neurology, Department of clinical Neuroscience, Geneva University Hospitals, 1205 Geneva, Switzerland
2
Neurodegenerative Studies Laboratory, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland
3
Department of Oncology, Geneva University Hospital and Medical School, 1205 Geneva, Switzerland
*
Author to whom correspondence should be addressed.
Academic Editor: Aaron Tan
Received: 11 March 2015 / Revised: 28 April 2015 / Accepted: 30 April 2015 / Published: 8 May 2015
(This article belongs to the Special Issue Artificial Organs)
View Full-Text   |   Download PDF [1519 KB, uploaded 8 May 2015]   |  

Abstract

Ex vivo gene therapy using retrievable encapsulated cellular implants is an effective strategy for the local and/or chronic delivery of therapeutic proteins. In particular, it is considered an innovative approach to modulate the activity of the immune system. Two recently proposed therapeutic schemes using genetically engineered encapsulated cells are discussed here: the chronic administration of monoclonal antibodies for passive immunization against neurodegenerative diseases and the local delivery of a cytokine as an adjuvant for anti-cancer vaccines. View Full-Text
Keywords: cellular implants; genetic engineering; encapsulation; passive immunization; recombinant antibodies; Alzheimer’s disease; cytokine; adjuvant; cancer vaccine cellular implants; genetic engineering; encapsulation; passive immunization; recombinant antibodies; Alzheimer’s disease; cytokine; adjuvant; cancer vaccine
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Lathuilière, A.; Mach, N.; Schneider, B.L. Encapsulated Cellular Implants for Recombinant Protein Delivery and Therapeutic Modulation of the Immune System. Int. J. Mol. Sci. 2015, 16, 10578-10600.

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