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Int. J. Mol. Sci. 2015, 16(4), 8227-8253; doi:10.3390/ijms16048227

MicroRNAs Regulate Bone Development and Regeneration

Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai 200011, China
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Author to whom correspondence should be addressed.
Academic Editor: Aaron Tan
Received: 27 January 2015 / Revised: 18 March 2015 / Accepted: 30 March 2015 / Published: 13 April 2015
(This article belongs to the Special Issue Artificial Organs)
View Full-Text   |   Download PDF [865 KB, uploaded 13 April 2015]   |  

Abstract

MicroRNAs (miRNAs) are endogenous small noncoding ~22-nt RNAs, which have been reported to play a crucial role in maintaining bone development and metabolism. Osteogenesis originates from mesenchymal stem cells (MSCs) differentiating into mature osteoblasts and each period of bone formation is inseparable from the delicate regulation of various miRNAs. Of note, apprehending the sophisticated circuit between miRNAs and osteogenic homeostasis is of great value for artificial skeletal regeneration for severe bone defects. In this review, we highlight how different miRNAs interact with diverse osteo-related genes and endeavor to sketch the contours of potential manipulations of miRNA-modulated bone repair. View Full-Text
Keywords: microRNA; osteogenesis; bone regeneration microRNA; osteogenesis; bone regeneration
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Fang, S.; Deng, Y.; Gu, P.; Fan, X. MicroRNAs Regulate Bone Development and Regeneration. Int. J. Mol. Sci. 2015, 16, 8227-8253.

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