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Int. J. Mol. Sci. 2015, 16(4), 7960-7975; doi:10.3390/ijms16047960

Synthesis of Spongy-Like Mesoporous Hydroxyapatite from Raw Waste Eggshells for Enhanced Dissolution of Ibuprofen Loaded via Supercritical CO2

Department of Chemical and Biochemical Engineering, College of Chemistry and Chemical Engineering, National Engineering Laboratory for Green Chemical Productions of Alcohols, Ethers and Esters, Xiamen University, Xiamen 361005, China
These authors contributed equally to this work.
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Author to whom correspondence should be addressed.
Academic Editor: Mohamed N. Rahaman
Received: 3 February 2015 / Revised: 31 March 2015 / Accepted: 3 April 2015 / Published: 9 April 2015
(This article belongs to the Special Issue Biomaterials for Tissue Engineering)
View Full-Text   |   Download PDF [1992 KB, uploaded 9 April 2015]   |  

Abstract

The use of cheaper and recyclable biomaterials (like eggshells) to synthesize high purity hydroxyapatite (HAp) with better properties (small particle size, large surface area and pore volume) for applications (in environmental remediation, bone augmentation and replacement, and drug delivery systems) is vital since high-purity synthetic calcium sources are expensive. In this work, pure and mesoporous HAp nanopowder with large pore volume (1.4 cm3/g) and surface area (284.1 m2/g) was produced from raw eggshells at room temperature using a simple two-step procedure. The control of precursor droplets could stabilize the pH value of the reaction solution, because of the size of the needle (of the syringe pump used for precursor additions) leading to production of HAp with high surface area and pore size. The as-produced HAp revealed high ibuprofen (as a model drug) loading (1.38 g/g HAp), enhanced dissolution and controllable release of the drug via solute-saturated supercritical carbon dioxide. View Full-Text
Keywords: hydroxyapatite; waste eggshell; ibuprofen; drug delivery; supercritical loading hydroxyapatite; waste eggshell; ibuprofen; drug delivery; supercritical loading
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Ibrahim, A.-R.; Li, X.; Zhou, Y.; Huang, Y.; Chen, W.; Wang, H.; Li, J. Synthesis of Spongy-Like Mesoporous Hydroxyapatite from Raw Waste Eggshells for Enhanced Dissolution of Ibuprofen Loaded via Supercritical CO2. Int. J. Mol. Sci. 2015, 16, 7960-7975.

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