Next Article in Journal
Expression and Effects of High-Mobility Group Box 1 in Cervical Cancer
Next Article in Special Issue
Adipose-Derived Stem Cells: A Review of Signaling Networks Governing Cell Fate and Regenerative Potential in the Context of Craniofacial and Long Bone Skeletal Repair
Previous Article in Journal
Geminal Brønsted Acid Ionic Liquids as Catalysts for the Mannich Reaction in Water
Previous Article in Special Issue
Lyophilized Platelet-Rich Fibrin (PRF) Promotes Craniofacial Bone Regeneration through Runx2
Article Menu

Export Article

Open AccessReview
Int. J. Mol. Sci. 2014, 15(5), 8667-8698; doi:10.3390/ijms15058667

Signaling Pathways in Cartilage Repair

1
Laboratory of Immunorheumatology and Tissue Regeneration/RAMSES, Rizzoli Orthopaedic Institute, via di Barbiano 1/10, Bologna 40136, Italy
2
Department of Medical and Surgical Sciences, University of Bologna, Bologna 40138, Italy
*
Author to whom correspondence should be addressed.
Received: 25 February 2014 / Revised: 28 April 2014 / Accepted: 4 May 2014 / Published: 15 May 2014
(This article belongs to the Special Issue Signal Transduction of Tissue Repair)
View Full-Text   |   Download PDF [367 KB, uploaded 19 June 2014]   |  

Abstract

In adult healthy cartilage, chondrocytes are in a quiescent phase characterized by a fine balance between anabolic and catabolic activities. In ageing, degenerative joint diseases and traumatic injuries of cartilage, a loss of homeostatic conditions and an up-regulation of catabolic pathways occur. Since cartilage differentiation and maintenance of homeostasis are finely tuned by a complex network of signaling molecules and biophysical factors, shedding light on these mechanisms appears to be extremely relevant for both the identification of pathogenic key factors, as specific therapeutic targets, and the development of biological approaches for cartilage regeneration. This review will focus on the main signaling pathways that can activate cellular and molecular processes, regulating the functional behavior of cartilage in both physiological and pathological conditions. These networks may be relevant in the crosstalk among joint compartments and increased knowledge in this field may lead to the development of more effective strategies for inducing cartilage repair. View Full-Text
Keywords: cartilage; signaling pathways; TGF-β/BMP; IGF; FGF; HIF; Wnt/β-catenin; NF-κB; MAPK; hedgehog cartilage; signaling pathways; TGF-β/BMP; IGF; FGF; HIF; Wnt/β-catenin; NF-κB; MAPK; hedgehog
Figures

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Mariani, E.; Pulsatelli, L.; Facchini, A. Signaling Pathways in Cartilage Repair. Int. J. Mol. Sci. 2014, 15, 8667-8698.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top