Next Article in Journal
Exercise Pretreatment Promotes Mitochondrial Dynamic Protein OPA1 Expression after Cerebral Ischemia in Rats
Previous Article in Journal
Transplanted Neural Stem Cells Modulate Regulatory T, γδ T Cells and Corresponding Cytokines after Intracerebral Hemorrhage in Rats
Previous Article in Special Issue
The Effect of Physical and Chemical Cues on Hepatocellular Function and Morphology
Int. J. Mol. Sci. 2014, 15(3), 4442-4452; doi:10.3390/ijms15034442

Comparison of the Osteogenic Potential of Titanium- and Modified Zirconia-Based Bioceramics

Received: 28 January 2014 / Revised: 6 March 2014 / Accepted: 10 March 2014 / Published: 13 March 2014
(This article belongs to the Special Issue Interaction between Nano-Structure Materials and Cells)
View Full-Text   |   Download PDF [554 KB, 19 June 2014; original version 19 June 2014]   |   Browse Figures


Zirconia is now favored over titanium for use in dental implant materials because of its superior aesthetic qualities. However, zirconia is susceptible to degradation at lower temperatures. In order to address this issue, we have developed modified zirconia implants that contain tantalum oxide or niobium oxide. Cells attached as efficiently to the zirconia implants as to titanium-based materials, irrespective of surface roughness. Cell proliferation on the polished surface was higher than that on the rough surfaces, but the converse was true for the osteogenic response. Cells on yttrium (Y)/tantalum (Ta)- and yttrium (Y)/niobium (Nb)-stabilized tetragonal zirconia polycrystals (TZP) discs ((Y, Ta)-TZP and (Y, Nb)-TZP, respectively) had a similar proliferative potential as those grown on anodized titanium. The osteogenic potential of MC3T3-E1 pre-osteoblast cells on (Y, Ta)-TZP and (Y, Nb)-TZP was similar to that of cells grown on rough-surface titanium. These data demonstrate that improved zirconia implants, which are resistant to temperature-induced degradation, retain the desirable clinical properties of structural stability and support of an osteogenic response.
Keywords: dental implant; titanium; zirconia; LTD; osteogenic potential dental implant; titanium; zirconia; LTD; osteogenic potential
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
MDPI and ACS Style

Cho, Y.-D.; Shin, J.-C.; Kim, H.-L.; Gerelmaa, M.; Yoon, H.-I.; Ryoo, H.-M.; Kim, D.-J.; Han, J.-S. Comparison of the Osteogenic Potential of Titanium- and Modified Zirconia-Based Bioceramics. Int. J. Mol. Sci. 2014, 15, 4442-4452.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


Cited By

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert