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Int. J. Mol. Sci. 2014, 15(3), 4453-4463; doi:10.3390/ijms15034453

Exercise Pretreatment Promotes Mitochondrial Dynamic Protein OPA1 Expression after Cerebral Ischemia in Rats

1
Department of Rehabilitation, Huashan Hospital, Fudan University, Shanghai 200040, China
2
State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 200032, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 21 January 2014 / Revised: 21 February 2014 / Accepted: 26 February 2014 / Published: 13 March 2014
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Abstract

Exercise training is a neuroprotective strategy in cerebral ischemic injury, but the underlying mechanisms are not yet clear. In the present study, we investigated the effects of treadmill exercise pretreatment on the expression of mitochondrial dynamic proteins. We examined the expression of OPA1/DLP1/MFF/Mfn1/Mfn2, which regulatesmitochondrial fusion and fission, and cytochrome C oxidase subunits (COX subunits), which regulatemitochondrial functions, after middle cerebral artery occlusion (MCAO) in rats. T2-weighted magnetic resonance imaging (MRI) was evaluated as indices of brain edema after ischemia as well. Treadmill training pretreatment increased the expression levels of OPA1 and COXII/III/IV and alleviated brain edema, indicating that exercise pretreatment provided neuroprotection in cerebral ischemic injury via the regulation of mitochondrial dynamics and functions. View Full-Text
Keywords: exercise pretreatment; mitochondrial dynamics; OPA1; cerebral ischemia; neuroprotection exercise pretreatment; mitochondrial dynamics; OPA1; cerebral ischemia; neuroprotection
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Zhang, L.; He, Z.; Zhang, Q.; Wu, Y.; Yang, X.; Niu, W.; Hu, Y.; Jia, J. Exercise Pretreatment Promotes Mitochondrial Dynamic Protein OPA1 Expression after Cerebral Ischemia in Rats. Int. J. Mol. Sci. 2014, 15, 4453-4463.

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