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Int. J. Mol. Sci. 2014, 15(3), 4453-4463; doi:10.3390/ijms15034453
Article

Exercise Pretreatment Promotes Mitochondrial Dynamic Protein OPA1 Expression after Cerebral Ischemia in Rats

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Received: 21 January 2014; in revised form: 21 February 2014 / Accepted: 26 February 2014 / Published: 13 March 2014
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Abstract: Exercise training is a neuroprotective strategy in cerebral ischemic injury, but the underlying mechanisms are not yet clear. In the present study, we investigated the effects of treadmill exercise pretreatment on the expression of mitochondrial dynamic proteins. We examined the expression of OPA1/DLP1/MFF/Mfn1/Mfn2, which regulatesmitochondrial fusion and fission, and cytochrome C oxidase subunits (COX subunits), which regulatemitochondrial functions, after middle cerebral artery occlusion (MCAO) in rats. T2-weighted magnetic resonance imaging (MRI) was evaluated as indices of brain edema after ischemia as well. Treadmill training pretreatment increased the expression levels of OPA1 and COXII/III/IV and alleviated brain edema, indicating that exercise pretreatment provided neuroprotection in cerebral ischemic injury via the regulation of mitochondrial dynamics and functions.
Keywords: exercise pretreatment; mitochondrial dynamics; OPA1; cerebral ischemia; neuroprotection exercise pretreatment; mitochondrial dynamics; OPA1; cerebral ischemia; neuroprotection
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Zhang, L.; He, Z.; Zhang, Q.; Wu, Y.; Yang, X.; Niu, W.; Hu, Y.; Jia, J. Exercise Pretreatment Promotes Mitochondrial Dynamic Protein OPA1 Expression after Cerebral Ischemia in Rats. Int. J. Mol. Sci. 2014, 15, 4453-4463.

AMA Style

Zhang L, He Z, Zhang Q, Wu Y, Yang X, Niu W, Hu Y, Jia J. Exercise Pretreatment Promotes Mitochondrial Dynamic Protein OPA1 Expression after Cerebral Ischemia in Rats. International Journal of Molecular Sciences. 2014; 15(3):4453-4463.

Chicago/Turabian Style

Zhang, Li; He, Zhijie; Zhang, Qi; Wu, Yi; Yang, Xiaojiao; Niu, Wenxiu; Hu, Yongshan; Jia, Jie. 2014. "Exercise Pretreatment Promotes Mitochondrial Dynamic Protein OPA1 Expression after Cerebral Ischemia in Rats." Int. J. Mol. Sci. 15, no. 3: 4453-4463.


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