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Int. J. Mol. Sci. 2014, 15(12), 22331-22341; doi:10.3390/ijms151222331

Discordance Rate of HER2 Status in Primary Gastric Carcinomas and Synchronous Lymph Node Metastases: A Multicenter Retrospective Analysis

1
Department of Human Pathology "Gaetano Barresi", Section of Anatomic Pathology, University of Messina, Messina 98123, Italy
2
Department "G.F. Ingrassia", Section of Anatomic Pathology, University of Catania, Catania 95123, Italy
3
Department of Medicine and Surgery, University of Salerno, Salerno 84131, Italy
4
Department of Diagnostic Medicine, Clinics and Public Health, Section of Pathologic Anatomy, University of Modena, Modena 41121, Italy
*
Author to whom correspondence should be addressed.
Received: 5 November 2014 / Revised: 24 November 2014 / Accepted: 27 November 2014 / Published: 3 December 2014
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
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Abstract

Background: The assessment of human epidermal growth factor receptor 2 (HER2) gene amplification is essential in order to identify those patients affected by advanced gastric cancer who may benefit from Trastuzumab targeted therapy. Materials and Methods: With the aim to investigate the concordance rate in HER2 status between primary gastric carcinoma (GC) and synchronous lymphnode metastases, we investigated HER2 status in a cohort of 108 surgical formalin-fixed paraffin-embedded specimens of GC and matched synchronous metastatic lymph nodes collected from three different units of Anatomic Pathology in southern of Italy. Fleiss-Cohen weighted k statistics were used to assess the concordance rate of HER2 status. Results: HER2 amplification was observed in 17% of primary GCs and the overall concordance rate with corresponding nodal metastases was 90.74%. Changes in HER2 status between primary GC and matched synchronous metastases were evidenced in 10 (9.26%) cases. Of these, 6 cases were HER2 amplified in the primary GC and not amplified in the metastases, while 4 were HER2 not amplified in the primary tumour and amplified in the lymph node metastases. Conclusions: Although at present the simultaneous determination of HER2 in advanced gastric cancer and corresponding metastatic lymph nodes is not mandatory, the possibility that the synchronous metastases of GC have a different HER2 status from that of the primary tumour is of remarkable significance; Indeed this may have influence on the therapeutic management and prognosis of the patients. View Full-Text
Keywords: human epidermal growth factor receptor 2 (HER2); gastric cancer; synchronous lymph nodes; metastases; prognosis human epidermal growth factor receptor 2 (HER2); gastric cancer; synchronous lymph nodes; metastases; prognosis
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Ieni, A.; Barresi, V.; Caltabiano, R.; Caleo, A.; Bonetti, L.R.; Lanzafame, S.; Zeppa, P.; Caruso, R.A.; Tuccari, G. Discordance Rate of HER2 Status in Primary Gastric Carcinomas and Synchronous Lymph Node Metastases: A Multicenter Retrospective Analysis. Int. J. Mol. Sci. 2014, 15, 22331-22341.

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