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Int. J. Mol. Sci. 2014, 15(12), 21865-21874; doi:10.3390/ijms151221865

Krempfielins Q and R, Two New Eunicellin-Based Diterpenoids from the Soft Coral Cladiella krempfi

Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan
Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University and Academia Sinica, Kaohsiung 804, Taiwan
Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan
National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan
Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan
Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 404, Taiwan
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
Author to whom correspondence should be addressed.
Received: 23 September 2014 / Revised: 12 November 2014 / Accepted: 21 November 2014 / Published: 27 November 2014
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
View Full-Text   |   Download PDF [953 KB, uploaded 27 November 2014]   |  


Two new eunicellin-based diterpenoids, krempfielins Q and R (1 and 2), and one known compound cladieunicellin K (3) have been isolated from a Formosan soft coral Cladiella krempfi. The structures of these two new metabolites were elucidated by extensive spectroscopic analysis. Anti-inflammatory activity of new metabolites to inhibit the superoxide anion generation and elastase release in N-formyl-methionyl-leucyl phenylalanine/cytochalasin B (FMLP/CB)-induced human neutrophil cells and cytotoxicity of both new compounds toward five cancer cell lines were reported. View Full-Text
Keywords: Cladiella krempfi; eunicellin-based diterpenoid; anti-inflammatory activity Cladiella krempfi; eunicellin-based diterpenoid; anti-inflammatory activity

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Tai, C.-J.; Chokkalingam, U.; Cheng, Y.; Shih, S.-P.; Lu, M.-C.; Su, J.-H.; Hwang, T.-L.; Sheu, J.-H. Krempfielins Q and R, Two New Eunicellin-Based Diterpenoids from the Soft Coral Cladiella krempfi. Int. J. Mol. Sci. 2014, 15, 21865-21874.

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