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Structural Properties of Polyphenols Causing Cell Cycle Arrest at G1 Phase in HCT116 Human Colorectal Cancer Cell Lines
Department of Biological Sciences, Konkuk University, Seoul 143-701, Korea
Division of Bioscience and Biotechnology, BMIC, Konkuk University, Seoul 143-701, Korea
Department of Applied Chemistry, Dongduk Women's University, Seoul 136-714, Korea
National Institute of Animal Science, Rural Development Administration, Suwon 441-706, Korea
These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 5 July 2013; in revised form: 6 August 2013 / Accepted: 9 August 2013 / Published: 19 August 2013
Abstract: Plant-derived polyphenols are being tested as chemopreventive agents; some polyphenols arrest the cell cycle at G1 phase, whereas others inhibit cell cycle proliferation at G2/M phase. Therefore, polyphenols have been proposed to inhibit cell cycle progression at different phases via distinct mechanisms. Indeed, our previous studies showed that small structural differences in polyphenols cause large differences in their biological activities; however, the details of the structural properties causing G1 cell cycle arrest remain unknown. In this study, we prepared 27 polyphenols, including eight different scaffolds, to gain insight into the structural conditions that arrest the cell cycle at G1 phase in a quantitative structure–activity relationship study. We used cell cycle profiles to determine the biophores responsible for G1 cell cycle arrest and believe that the biophores identified in this study will help design polyphenols that cause G1 cell cycle arrest.
Keywords: polyphenols; flavonoids; colorectal cancer; cell cycle; QSAR
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Shin, S.Y.; Yoon, H.; Ahn, S.; Kim, D.-W.; Bae, D.-H.; Koh, D.; Lee, Y.H.; Lim, Y. Structural Properties of Polyphenols Causing Cell Cycle Arrest at G1 Phase in HCT116 Human Colorectal Cancer Cell Lines. Int. J. Mol. Sci. 2013, 14, 16970-16985.
Shin SY, Yoon H, Ahn S, Kim D-W, Bae D-H, Koh D, Lee YH, Lim Y. Structural Properties of Polyphenols Causing Cell Cycle Arrest at G1 Phase in HCT116 Human Colorectal Cancer Cell Lines. International Journal of Molecular Sciences. 2013; 14(8):16970-16985.
Shin, Soon Y.; Yoon, Hyuk; Ahn, Seunghyun; Kim, Dong-Wook; Bae, Dong-Ho; Koh, Dongsoo; Lee, Young H.; Lim, Yoongho. 2013. "Structural Properties of Polyphenols Causing Cell Cycle Arrest at G1 Phase in HCT116 Human Colorectal Cancer Cell Lines." Int. J. Mol. Sci. 14, no. 8: 16970-16985.