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Molecular Pathways Involved in Colorectal Cancer: Implications for Disease Behavior and Prevention
Department of Medical and Surgical Sciences, University of Bologna, Via Massarenti 9, Pad 5, Bologna 40138, Italy
Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Via Massarenti 9, Pad 5, Bologna 40138, Italy
* Author to whom correspondence should be addressed.
Received: 22 July 2013; in revised form: 25 July 2013 / Accepted: 26 July 2013 / Published: 7 August 2013
Abstract: Research conducted during the past 30 years has increased our understanding of the mechanisms involved in colorectal cancer initiation and development. The findings have demonstrated the existence of at least three pathways: chromosomal instability, microsatellite instability and CpG island methylator phenotype. Importantly, new studies have shown that inflammation and microRNAs contribute to colorectal carcinogenesis. Recent data have demonstrated that several genetic and epigenetic changes are important in determining patient prognosis and survival. Furthermore, some of these mechanisms are related to patients’ response to drugs, such as aspirin, which could be used for both chemoprevention and treatment in specific settings. Thus, in the near future, we could be able to predict disease behavior based on molecular markers found on tumors, and direct the best treatment options for patients.
Keywords: colorectal cancer; chromosomal instability; microsatellite instability; DNA methylation; aspirin
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Colussi, D.; Brandi, G.; Bazzoli, F.; Ricciardiello, L. Molecular Pathways Involved in Colorectal Cancer: Implications for Disease Behavior and Prevention. Int. J. Mol. Sci. 2013, 14, 16365-16385.
Colussi D, Brandi G, Bazzoli F, Ricciardiello L. Molecular Pathways Involved in Colorectal Cancer: Implications for Disease Behavior and Prevention. International Journal of Molecular Sciences. 2013; 14(8):16365-16385.
Colussi, Dora; Brandi, Giovanni; Bazzoli, Franco; Ricciardiello, Luigi. 2013. "Molecular Pathways Involved in Colorectal Cancer: Implications for Disease Behavior and Prevention." Int. J. Mol. Sci. 14, no. 8: 16365-16385.