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Potential Targets for Colorectal Cancer Prevention
Division of Hematology/Oncology, American University of Beirut Medical Center (AUBMC), Beirut 1107 2020, Lebanon
* Author to whom correspondence should be addressed.
Received: 15 July 2013; in revised form: 9 August 2013 / Accepted: 14 August 2013 / Published: 22 August 2013
Abstract: The step-wise development of colorectal neoplasia from adenoma to carcinoma suggests that specific interventions could delay or prevent the development of invasive cancer. Several key factors involved in colorectal cancer pathogenesis have already been identified including cyclooxygenase 2 (COX-2), nuclear factor kappa B (NF-κB), survivin and insulin-like growth factor-I (IGF-I). Clinical trials of COX-2 inhibitors have provided the “proof of principle” that inhibition of this enzyme can prevent the formation of colonic adenomas and potentially carcinomas, however concerns regarding the potential toxicity of these drugs have limited their use as a chemopreventative strategy. Curcumin, resveratrol and quercetin are chemopreventive agents that are able to suppress multiple signaling pathways involved in carcinogenesis and hence are attractive candidates for further research.
Keywords: chemoprevention; colorectal cancer; NSAIDs; aspirin; natural compounds; COX-2; NF-κB ; survivin; IGF-1
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MDPI and ACS Style
Temraz, S.; Mukherji, D.; Shamseddine, A. Potential Targets for Colorectal Cancer Prevention. Int. J. Mol. Sci. 2013, 14, 17279-17303.
Temraz S, Mukherji D, Shamseddine A. Potential Targets for Colorectal Cancer Prevention. International Journal of Molecular Sciences. 2013; 14(9):17279-17303.
Temraz, Sally; Mukherji, Deborah; Shamseddine, Ali. 2013. "Potential Targets for Colorectal Cancer Prevention." Int. J. Mol. Sci. 14, no. 9: 17279-17303.