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Epigenetics Meets Radiation Biology as a New Approach in Cancer Treatment
Research Center, Dongnam Institute of Radiological & Medical Sciences (DIRAMS), Busan 619-953, Korea
Radiological Oncology, Dongnam Institute of Radiological & Medical Sciences (DIRAMS), Busan 619-953, Korea
* Author to whom correspondence should be addressed.
Received: 13 June 2013; in revised form: 10 July 2013 / Accepted: 15 July 2013 / Published: 18 July 2013
Abstract: Cancer is a disease that results from both genetic and epigenetic changes. In recent decades, a number of people have investigated the disparities in gene expression resulting from variable DNA methylation alteration and chromatin structure modification in response to the environment. Especially, colon cancer is a great model system for investigating the epigenetic mechanism for aberrant gene expression alteration. Ionizing radiation (IR) could affect a variety of processes within exposed cells and, in particular, cause changes in gene expression, disruption of cell cycle arrest, and apoptotic cell death. Even though there is growing evidence on the importance of epigenetics and biological processes induced by radiation exposure in various cancer types including colon cancer, specific epigenetic alterations induced by radiation at the molecular level are incompletely defined. This review focuses on discussing possible IR-mediated changes of DNA methylation and histone modification in cancer.
Keywords: epigenetic regulation; DNA methylation; histone modification; radiation exposure; cancer; colon cancer
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MDPI and ACS Style
Kim, J.-G.; Park, M.-T.; Heo, K.; Yang, K.-M.; Yi, J.M. Epigenetics Meets Radiation Biology as a New Approach in Cancer Treatment. Int. J. Mol. Sci. 2013, 14, 15059-15073.
Kim J-G, Park M-T, Heo K, Yang K-M, Yi JM. Epigenetics Meets Radiation Biology as a New Approach in Cancer Treatment. International Journal of Molecular Sciences. 2013; 14(7):15059-15073.
Kim, Joong-Gook; Park, Moon-Taek; Heo, Kyu; Yang, Kwang-Mo; Yi, Joo M. 2013. "Epigenetics Meets Radiation Biology as a New Approach in Cancer Treatment." Int. J. Mol. Sci. 14, no. 7: 15059-15073.