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Int. J. Mol. Sci. 2013, 14(7), 15059-15073; doi:10.3390/ijms140715059

Epigenetics Meets Radiation Biology as a New Approach in Cancer Treatment

1
Research Center, Dongnam Institute of Radiological & Medical Sciences (DIRAMS), Busan 619-953, Korea
2
Radiological Oncology, Dongnam Institute of Radiological & Medical Sciences (DIRAMS), Busan 619-953, Korea
*
Author to whom correspondence should be addressed.
Received: 13 June 2013 / Revised: 10 July 2013 / Accepted: 15 July 2013 / Published: 18 July 2013
(This article belongs to the Special Issue Pathogenesis and Prevention of Colorectal Cancer)
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Abstract

Cancer is a disease that results from both genetic and epigenetic changes. In recent decades, a number of people have investigated the disparities in gene expression resulting from variable DNA methylation alteration and chromatin structure modification in response to the environment. Especially, colon cancer is a great model system for investigating the epigenetic mechanism for aberrant gene expression alteration. Ionizing radiation (IR) could affect a variety of processes within exposed cells and, in particular, cause changes in gene expression, disruption of cell cycle arrest, and apoptotic cell death. Even though there is growing evidence on the importance of epigenetics and biological processes induced by radiation exposure in various cancer types including colon cancer, specific epigenetic alterations induced by radiation at the molecular level are incompletely defined. This review focuses on discussing possible IR-mediated changes of DNA methylation and histone modification in cancer. View Full-Text
Keywords: epigenetic regulation; DNA methylation; histone modification; radiation exposure; cancer; colon cancer epigenetic regulation; DNA methylation; histone modification; radiation exposure; cancer; colon cancer
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Kim, J.-G.; Park, M.-T.; Heo, K.; Yang, K.-M.; Yi, J.M. Epigenetics Meets Radiation Biology as a New Approach in Cancer Treatment. Int. J. Mol. Sci. 2013, 14, 15059-15073.

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