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Magnetic Iron Oxide Nanoparticles for Multimodal Imaging and Therapy of Cancer
Department of Radiology, Chonnam National University Hwasun Hospital, Chonnam National University Medical School, Gwangju 501-746, Korea
Department of Biomedical Science, Research Institute of Medical Sciences, Chonnam National University Medical School, Gwangju 501-746, Korea
* Author to whom correspondence should be addressed.
Received: 23 May 2013; in revised form: 16 July 2013 / Accepted: 18 July 2013 / Published: 31 July 2013
Abstract: Superparamagnetic iron oxide nanoparticles (SPION) have emerged as an MRI contrast agent for tumor imaging due to their efficacy and safety. Their utility has been proven in clinical applications with a series of marketed SPION-based contrast agents. Extensive research has been performed to study various strategies that could improve SPION by tailoring the surface chemistry and by applying additional therapeutic functionality. Research into the dual-modal contrast uses of SPION has developed because these applications can save time and effort by reducing the number of imaging sessions. In addition to multimodal strategies, efforts have been made to develop multifunctional nanoparticles that carry both diagnostic and therapeutic cargos specifically for cancer. This review provides an overview of recent advances in multimodality imaging agents and focuses on iron oxide based nanoparticles and their theranostic applications for cancer. Furthermore, we discuss the physiochemical properties and compare different synthesis methods of SPION for the development of multimodal contrast agents.
Keywords: SPION; multimodal; multifunctional; theranostics; MRI; CT; SPECT; PET
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MDPI and ACS Style
Thomas, R.; Park, I.-K.; Jeong, Y.Y. Magnetic Iron Oxide Nanoparticles for Multimodal Imaging and Therapy of Cancer. Int. J. Mol. Sci. 2013, 14, 15910-15930.
Thomas R, Park I-K, Jeong YY. Magnetic Iron Oxide Nanoparticles for Multimodal Imaging and Therapy of Cancer. International Journal of Molecular Sciences. 2013; 14(8):15910-15930.
Thomas, Reju; Park, In-Kyu; Jeong, Yong Y. 2013. "Magnetic Iron Oxide Nanoparticles for Multimodal Imaging and Therapy of Cancer." Int. J. Mol. Sci. 14, no. 8: 15910-15930.