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Int. J. Mol. Sci. 2013, 14(8), 15910-15930; doi:10.3390/ijms140815910

Magnetic Iron Oxide Nanoparticles for Multimodal Imaging and Therapy of Cancer

Received: 23 May 2013 / Revised: 16 July 2013 / Accepted: 18 July 2013 / Published: 31 July 2013
(This article belongs to the Special Issue Magnetic Nanoparticles 2013)
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Superparamagnetic iron oxide nanoparticles (SPION) have emerged as an MRI contrast agent for tumor imaging due to their efficacy and safety. Their utility has been proven in clinical applications with a series of marketed SPION-based contrast agents. Extensive research has been performed to study various strategies that could improve SPION by tailoring the surface chemistry and by applying additional therapeutic functionality. Research into the dual-modal contrast uses of SPION has developed because these applications can save time and effort by reducing the number of imaging sessions. In addition to multimodal strategies, efforts have been made to develop multifunctional nanoparticles that carry both diagnostic and therapeutic cargos specifically for cancer. This review provides an overview of recent advances in multimodality imaging agents and focuses on iron oxide based nanoparticles and their theranostic applications for cancer. Furthermore, we discuss the physiochemical properties and compare different synthesis methods of SPION for the development of multimodal contrast agents.
Keywords: SPION; multimodal; multifunctional; theranostics; MRI; CT; SPECT; PET SPION; multimodal; multifunctional; theranostics; MRI; CT; SPECT; PET
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Thomas, R.; Park, I.-K.; Jeong, Y.Y. Magnetic Iron Oxide Nanoparticles for Multimodal Imaging and Therapy of Cancer. Int. J. Mol. Sci. 2013, 14, 15910-15930.

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Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert