Int. J. Mol. Sci. 2013, 14(8), 15199-15211; doi:10.3390/ijms140815199
Article

Anti-Inflammatory Activity of N-(3-Florophenyl)ethylcaffeamide in Mice

Received: 4 June 2013; in revised form: 4 July 2013 / Accepted: 16 July 2013 / Published: 24 July 2013
(This article belongs to the Section Bioactives and Nutraceuticals)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: In this study, we evaluated the anti-inflammatory activity of one synthetic product, N-(3-Florophenyl)ethylcaffeamide (abbrev. FECA), by using animal model of λ-carrageenan-induced paw edema in mice. The anti-inflammatory mechanism of FECA was determined by measuring the levels of cyclooxygenase-2 (COX-2), nitric oxide (NO), tumor necrosis factor (TNF-α), interleukin-1β (IL-1β), and malondialdehyde (MDA) in the edema paw tissue, and the activities of superoxide dismutase (SOD), glutathione peroxidase (GPx), and glutathione reductase (GRd) in the liver. The results showed that FECA reduced the paw edema at three, four and five hours after λ-carrageenan administration. The levels of COX-2, NO, TNF-α, and MDA in the λ-carrageenan-induced edema paws were reduced and the activities of SOD, GPx, and GRd in liver tissues were raised by FECA. These results suggested that FECA possessed anti-inflammatory activities and the anti-inflammatory mechanisms might be related to the decrease of the levels of COX-2, NO, and TNF-α in inflamed tissues and the increase in the MDA level by increasing the activities of SOD, GPx, and GRd.
Keywords: anti-inflammatory; caffeamide; synthesis
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MDPI and ACS Style

Liao, J.-C.; Tsai, J.-C.; Peng, W.-H.; Chiu, Y.-J.; Sung, P.-J.; Tsuzoki, M.; Kuo, Y.-H. Anti-Inflammatory Activity of N-(3-Florophenyl)ethylcaffeamide in Mice. Int. J. Mol. Sci. 2013, 14, 15199-15211.

AMA Style

Liao J-C, Tsai J-C, Peng W-H, Chiu Y-J, Sung P-J, Tsuzoki M, Kuo Y-H. Anti-Inflammatory Activity of N-(3-Florophenyl)ethylcaffeamide in Mice. International Journal of Molecular Sciences. 2013; 14(8):15199-15211.

Chicago/Turabian Style

Liao, Jung-Chun; Tsai, Jen-Chieh; Peng, Wen-Huang; Chiu, Yung-Jia; Sung, Ping-Jyun; Tsuzoki, Minoru; Kuo, Yueh-Hsiung. 2013. "Anti-Inflammatory Activity of N-(3-Florophenyl)ethylcaffeamide in Mice." Int. J. Mol. Sci. 14, no. 8: 15199-15211.

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