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Int. J. Mol. Sci. 2013, 14(8), 15199-15211; doi:10.3390/ijms140815199

Anti-Inflammatory Activity of N-(3-Florophenyl)ethylcaffeamide in Mice

1
School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan
2
Department of Health and Nutrition Biotechnology, College of Health Science, Asia University, Taichung 404, Taiwan
3
Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Pharmacy, China Medical University, Taichung 404, Taiwan
4
National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan
5
Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan
6
Nihon Pharmaceutica University, Saitama 362-0806, Japan
7
Tsuzuki Institute for Traditional Medicine, China Medical University, Taichung 404, Taiwan
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 4 June 2013 / Revised: 4 July 2013 / Accepted: 16 July 2013 / Published: 24 July 2013
(This article belongs to the Section Biochemistry, Molecular Biology and Biophysics)
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Abstract

In this study, we evaluated the anti-inflammatory activity of one synthetic product, N-(3-Florophenyl)ethylcaffeamide (abbrev. FECA), by using animal model of λ-carrageenan-induced paw edema in mice. The anti-inflammatory mechanism of FECA was determined by measuring the levels of cyclooxygenase-2 (COX-2), nitric oxide (NO), tumor necrosis factor (TNF-α), interleukin-1β (IL-1β), and malondialdehyde (MDA) in the edema paw tissue, and the activities of superoxide dismutase (SOD), glutathione peroxidase (GPx), and glutathione reductase (GRd) in the liver. The results showed that FECA reduced the paw edema at three, four and five hours after λ-carrageenan administration. The levels of COX-2, NO, TNF-α, and MDA in the λ-carrageenan-induced edema paws were reduced and the activities of SOD, GPx, and GRd in liver tissues were raised by FECA. These results suggested that FECA possessed anti-inflammatory activities and the anti-inflammatory mechanisms might be related to the decrease of the levels of COX-2, NO, and TNF-α in inflamed tissues and the increase in the MDA level by increasing the activities of SOD, GPx, and GRd.
Keywords: anti-inflammatory; caffeamide; synthesis anti-inflammatory; caffeamide; synthesis
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Liao, J.-C.; Tsai, J.-C.; Peng, W.-H.; Chiu, Y.-J.; Sung, P.-J.; Tsuzoki, M.; Kuo, Y.-H. Anti-Inflammatory Activity of N-(3-Florophenyl)ethylcaffeamide in Mice. Int. J. Mol. Sci. 2013, 14, 15199-15211.

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