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Clinical Advances in Molecular Biomarkers for Cancer Diagnosis and Therapy
Int. J. Mol. Sci. 2013, 14(7), 15029-15058; doi:10.3390/ijms140715029
Review

DNA Methylation and Cancer Diagnosis

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Received: 10 May 2013; in revised form: 28 June 2013 / Accepted: 4 July 2013 / Published: 18 July 2013
(This article belongs to the Special Issue Advances in Cancer Diagnosis)
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Abstract: DNA methylation is a major epigenetic modification that is strongly involved in the physiological control of genome expression. DNA methylation patterns are largely modified in cancer cells and can therefore be used to distinguish cancer cells from normal tissues. This review describes the main technologies available for the detection and the discovery of aberrantly methylated DNA patterns. It also presents the different sources of biological samples suitable for DNA methylation studies. We discuss the interest and perspectives on the use of DNA methylation measurements for cancer diagnosis through examples of methylated genes commonly documented in the literature. The discussion leads to our consideration for why DNA methylation is not commonly used in clinical practice through an examination of the main requirements that constitute a reliable biomarker. Finally, we describe the main DNA methylation inhibitors currently used in clinical trials and those that exhibit promising results.
Keywords: DNA methylation; biomarkers; cancer diagnosis; DNA methylation inhibitors; clinical trials DNA methylation; biomarkers; cancer diagnosis; DNA methylation inhibitors; clinical trials
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Delpu, Y.; Cordelier, P.; Cho, W.C.; Torrisani, J. DNA Methylation and Cancer Diagnosis. Int. J. Mol. Sci. 2013, 14, 15029-15058.

AMA Style

Delpu Y, Cordelier P, Cho WC, Torrisani J. DNA Methylation and Cancer Diagnosis. International Journal of Molecular Sciences. 2013; 14(7):15029-15058.

Chicago/Turabian Style

Delpu, Yannick; Cordelier, Pierre; Cho, William C.; Torrisani, Jérôme. 2013. "DNA Methylation and Cancer Diagnosis." Int. J. Mol. Sci. 14, no. 7: 15029-15058.


Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert