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Int. J. Mol. Sci. 2013, 14(7), 15017-15028; doi:10.3390/ijms140715017
Article

Effect of a Static Magnetic Fields and Fluoride Ions on the Antioxidant Defense System of Mice Fibroblasts

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Received: 13 June 2013; in revised form: 8 July 2013 / Accepted: 11 July 2013 / Published: 18 July 2013
(This article belongs to the collection Radiation Toxicity in Cells)
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Abstract: The results of studies on the biological influence of magnetic fields are controversial and do not provide clear answers regarding their impact on cell functioning. Fluoride compounds are substances that influence free radical processes, which occur when the reactive forms of oxygen are present. It is not known whether static magnetic fields (SMF) cause any changes in fluoride assimilation or activity. Therefore, the aim of this work was to determine the potential relationship between magnetic field exposure to, and the antioxidant system of, fibroblasts cultured with fluoride ions. Three chambers with static magnetic fields of different intensities (0.4, 0.6, and 0.7 T) were used in this work. Fluoride ions were added at a concentration of 0.12 mM, which did not cause the precipitation of calcium or magnesium. The results of this study show that static magnetic fields reduce the oxidative stress caused by fluoride ions and normalize the activities of antioxidant enzymes, including superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT). Static magnetic fields modify the energy state of fibroblasts, causing an increase in the ATP concentration and a decrease in the MDA concentration. These results suggest that exposure to fluoride and an SMF improves the tolerance of cells to the oxidative stress induced by fluoride ions.
Keywords: static magnetic fields (SMF); fluoride; rat fibroblasts; redox homeostasis static magnetic fields (SMF); fluoride; rat fibroblasts; redox homeostasis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Kurzeja, E.; Synowiec-Wojtarowicz, A.; Stec, M.; Glinka, M.; Gawron, S.; Pawłowska-Góral, K. Effect of a Static Magnetic Fields and Fluoride Ions on the Antioxidant Defense System of Mice Fibroblasts. Int. J. Mol. Sci. 2013, 14, 15017-15028.

AMA Style

Kurzeja E, Synowiec-Wojtarowicz A, Stec M, Glinka M, Gawron S, Pawłowska-Góral K. Effect of a Static Magnetic Fields and Fluoride Ions on the Antioxidant Defense System of Mice Fibroblasts. International Journal of Molecular Sciences. 2013; 14(7):15017-15028.

Chicago/Turabian Style

Kurzeja, Ewa; Synowiec-Wojtarowicz, Agnieszka; Stec, Małgorzata; Glinka, Marek; Gawron, Stanisław; Pawłowska-Góral, Katarzyna. 2013. "Effect of a Static Magnetic Fields and Fluoride Ions on the Antioxidant Defense System of Mice Fibroblasts." Int. J. Mol. Sci. 14, no. 7: 15017-15028.



Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert