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Effect of a Static Magnetic Fields and Fluoride Ions on the Antioxidant Defense System of Mice Fibroblasts
Department of Food and Nutrition, Medical University of Silesia in Katowice, 8 Jednosci Street, 41-200 Sosnowiec, Poland
Research and Development Centre of Electrical Machines, 188 Rozdzienskiego Street, 40-203 Katowice, Poland
* Author to whom correspondence should be addressed.
Received: 13 June 2013; in revised form: 8 July 2013 / Accepted: 11 July 2013 / Published: 18 July 2013
Abstract: The results of studies on the biological influence of magnetic fields are controversial and do not provide clear answers regarding their impact on cell functioning. Fluoride compounds are substances that influence free radical processes, which occur when the reactive forms of oxygen are present. It is not known whether static magnetic fields (SMF) cause any changes in fluoride assimilation or activity. Therefore, the aim of this work was to determine the potential relationship between magnetic field exposure to, and the antioxidant system of, fibroblasts cultured with fluoride ions. Three chambers with static magnetic fields of different intensities (0.4, 0.6, and 0.7 T) were used in this work. Fluoride ions were added at a concentration of 0.12 mM, which did not cause the precipitation of calcium or magnesium. The results of this study show that static magnetic fields reduce the oxidative stress caused by fluoride ions and normalize the activities of antioxidant enzymes, including superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT). Static magnetic fields modify the energy state of fibroblasts, causing an increase in the ATP concentration and a decrease in the MDA concentration. These results suggest that exposure to fluoride and an SMF improves the tolerance of cells to the oxidative stress induced by fluoride ions.
Keywords: static magnetic fields (SMF); fluoride; rat fibroblasts; redox homeostasis
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Kurzeja, E.; Synowiec-Wojtarowicz, A.; Stec, M.; Glinka, M.; Gawron, S.; Pawłowska-Góral, K. Effect of a Static Magnetic Fields and Fluoride Ions on the Antioxidant Defense System of Mice Fibroblasts. Int. J. Mol. Sci. 2013, 14, 15017-15028.
Kurzeja E, Synowiec-Wojtarowicz A, Stec M, Glinka M, Gawron S, Pawłowska-Góral K. Effect of a Static Magnetic Fields and Fluoride Ions on the Antioxidant Defense System of Mice Fibroblasts. International Journal of Molecular Sciences. 2013; 14(7):15017-15028.
Kurzeja, Ewa; Synowiec-Wojtarowicz, Agnieszka; Stec, Małgorzata; Glinka, Marek; Gawron, Stanisław; Pawłowska-Góral, Katarzyna. 2013. "Effect of a Static Magnetic Fields and Fluoride Ions on the Antioxidant Defense System of Mice Fibroblasts." Int. J. Mol. Sci. 14, no. 7: 15017-15028.