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Neuroprotective Effect of Melatonin: A Novel Therapy against Perinatal Hypoxia-Ischemia
Department of Cell Biology and Histology, School of Medicine and Dentistry, University of the Basque Country, Barrio Sarriena s/n, Leioa 48940, Bizkaia, Spain
* Author to whom correspondence should be addressed.
Received: 28 February 2013; in revised form: 15 April 2013 / Accepted: 16 April 2013 / Published: 29 April 2013
Abstract: One of the most common causes of mortality and morbidity in children is perinatal hypoxia-ischemia (HI). In spite of the advances in neonatology, its incidence is not diminishing, generating a pediatric population that will require an extended amount of chronic care throughout their lifetime. For this reason, new and more effective neuroprotective strategies are urgently required, in order to minimize as much as possible the neurological consequences of this encephalopathy. In this sense, interest has grown in the neuroprotective possibilities of melatonin, as this hormone may help to maintain cell survival through the modulation of a wide range of physiological functions. Although some of the mechanisms by which melatonin is neuroprotective after neonatal asphyxia remain a subject of investigation, this review tries to summarize some of the most recent advances related with its use as a therapeutic drug against perinatal hypoxic-ischemic brain injury, supporting the high interest in this indoleamine as a future feasible strategy for cerebral asphyctic events.
Keywords: melatonin; neuroprotection; hypoxia-ischemia; newborn
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Alonso-Alconada, D.; Álvarez, A.; Arteaga, O.; Martínez-Ibargüen, A.; Hilario, E. Neuroprotective Effect of Melatonin: A Novel Therapy against Perinatal Hypoxia-Ischemia. Int. J. Mol. Sci. 2013, 14, 9379-9395.
Alonso-Alconada D, Álvarez A, Arteaga O, Martínez-Ibargüen A, Hilario E. Neuroprotective Effect of Melatonin: A Novel Therapy against Perinatal Hypoxia-Ischemia. International Journal of Molecular Sciences. 2013; 14(5):9379-9395.
Alonso-Alconada, Daniel; Álvarez, Antonia; Arteaga, Olatz; Martínez-Ibargüen, Agustín; Hilario, Enrique. 2013. "Neuroprotective Effect of Melatonin: A Novel Therapy against Perinatal Hypoxia-Ischemia." Int. J. Mol. Sci. 14, no. 5: 9379-9395.