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Int. J. Mol. Sci. 2013, 14(5), 10063-10074; doi:10.3390/ijms140510063
Review

Melatonin Effects on Hard Tissues: Bone and Tooth

1,2
, 1,2,*  and 1,2,*
Received: 22 March 2013; in revised form: 29 April 2013 / Accepted: 2 May 2013 / Published: 10 May 2013
(This article belongs to the Special Issue Advances in the Research of Melatonin)
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Abstract: Melatonin is an endogenous hormone rhythmically produced in the pineal gland under the control of the suprachiasmatic nucleus (SCN) and the light/dark cycle. This indole plays an important role in many physiological processes including circadian entrainment, blood pressure regulation, seasonal reproduction, ovarian physiology, immune function, etc. Recently, the investigation and applications of melatonin in the hard tissues bone and tooth have received great attention. Melatonin has been investigated relative to bone remolding, osteoporosis, osseointegration of dental implants and dentine formation. In the present review, we discuss the large body of published evidence and review data of melatonin effects on hard tissues, specifically, bone and tooth.
Keywords: melatonin; bone remolding; osteoporosis; tooth development; osseointegration melatonin; bone remolding; osteoporosis; tooth development; osseointegration
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Liu, J.; Huang, F.; He, H.-W. Melatonin Effects on Hard Tissues: Bone and Tooth. Int. J. Mol. Sci. 2013, 14, 10063-10074.

AMA Style

Liu J, Huang F, He H-W. Melatonin Effects on Hard Tissues: Bone and Tooth. International Journal of Molecular Sciences. 2013; 14(5):10063-10074.

Chicago/Turabian Style

Liu, Jie; Huang, Fang; He, Hong-Wen. 2013. "Melatonin Effects on Hard Tissues: Bone and Tooth." Int. J. Mol. Sci. 14, no. 5: 10063-10074.



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