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Int. J. Mol. Sci. 2013, 14(5), 10063-10074; doi:10.3390/ijms140510063
Review

Melatonin Effects on Hard Tissues: Bone and Tooth

1,2
,
1,2,*  and 1,2,*
1 Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangzhou 510055, China 2 Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510080, China
* Authors to whom correspondence should be addressed.
Received: 22 March 2013 / Revised: 29 April 2013 / Accepted: 2 May 2013 / Published: 10 May 2013
(This article belongs to the Special Issue Advances in the Research of Melatonin)
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Abstract

Melatonin is an endogenous hormone rhythmically produced in the pineal gland under the control of the suprachiasmatic nucleus (SCN) and the light/dark cycle. This indole plays an important role in many physiological processes including circadian entrainment, blood pressure regulation, seasonal reproduction, ovarian physiology, immune function, etc. Recently, the investigation and applications of melatonin in the hard tissues bone and tooth have received great attention. Melatonin has been investigated relative to bone remolding, osteoporosis, osseointegration of dental implants and dentine formation. In the present review, we discuss the large body of published evidence and review data of melatonin effects on hard tissues, specifically, bone and tooth.
Keywords: melatonin; bone remolding; osteoporosis; tooth development; osseointegration melatonin; bone remolding; osteoporosis; tooth development; osseointegration
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Liu, J.; Huang, F.; He, H.-W. Melatonin Effects on Hard Tissues: Bone and Tooth. Int. J. Mol. Sci. 2013, 14, 10063-10074.

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