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Int. J. Mol. Sci. 2013, 14(5), 10674-10682; doi:10.3390/ijms140510674
Review

New Advances in Urea Transporter UT-A1 Membrane Trafficking

Department of Physiology, Emory University School of Medicine, Atlanta, GA 30322, USA
Received: 22 April 2013 / Revised: 9 May 2013 / Accepted: 9 May 2013 / Published: 21 May 2013
(This article belongs to the Special Issue Regulation of Membrane Trafficking and Its Potential Implications)
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Abstract

The vasopressin-regulated urea transporter UT-A1, expressed in kidney inner medullary collecting duct (IMCD) epithelial cells, plays a critical role in the urinary concentrating mechanisms. As a membrane protein, the function of UT-A1 transport activity relies on its presence in the plasma membrane. Therefore, UT-A1 successfully trafficking to the apical membrane of the polarized epithelial cells is crucial for the regulation of urea transport. This review summarizes the research progress of UT-A1 regulation over the past few years, specifically on the regulation of UT-A1 membrane trafficking by lipid rafts, N-linked glycosylation and a group of accessory proteins.
Keywords: lipid rafts; glycosylation; accessory proteins; SNARE protein; cytoskeleton protein lipid rafts; glycosylation; accessory proteins; SNARE protein; cytoskeleton protein
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Chen, G. New Advances in Urea Transporter UT-A1 Membrane Trafficking. Int. J. Mol. Sci. 2013, 14, 10674-10682.

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