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Int. J. Mol. Sci. 2013, 14(5), 10674-10682; doi:10.3390/ijms140510674
Review

New Advances in Urea Transporter UT-A1 Membrane Trafficking

Received: 22 April 2013 / Revised: 9 May 2013 / Accepted: 9 May 2013 / Published: 21 May 2013
(This article belongs to the Special Issue Regulation of Membrane Trafficking and Its Potential Implications)
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Abstract

The vasopressin-regulated urea transporter UT-A1, expressed in kidney inner medullary collecting duct (IMCD) epithelial cells, plays a critical role in the urinary concentrating mechanisms. As a membrane protein, the function of UT-A1 transport activity relies on its presence in the plasma membrane. Therefore, UT-A1 successfully trafficking to the apical membrane of the polarized epithelial cells is crucial for the regulation of urea transport. This review summarizes the research progress of UT-A1 regulation over the past few years, specifically on the regulation of UT-A1 membrane trafficking by lipid rafts, N-linked glycosylation and a group of accessory proteins.
Keywords: lipid rafts; glycosylation; accessory proteins; SNARE protein; cytoskeleton protein lipid rafts; glycosylation; accessory proteins; SNARE protein; cytoskeleton protein
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Chen, G. New Advances in Urea Transporter UT-A1 Membrane Trafficking. Int. J. Mol. Sci. 2013, 14, 10674-10682.

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