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Evaluation of the Effect of Different Doses of Low Energy Shock Wave Therapy on the Erectile Function of Streptozotocin (STZ)-Induced Diabetic Rats
Andrology Center, Peking University First Hospital, Peking University, Beijing 100034, China
Department of Urology, First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu, China
Department of Urology, General Hospital of Ningxia Medical University, Yinchuan 750004, Ningxia, China
Department of Urology, China-Japan Union Hospital of Jilin University, Changchun 130033, Jilin, China
* Author to whom correspondence should be addressed.
Received: 14 February 2013; in revised form: 4 May 2013 / Accepted: 8 May 2013 / Published: 21 May 2013
Abstract: To investigate the therapeutic effect of different doses of low energy shock wave therapy (LESWT) on the erectile dysfunction (ED) in streptozotocin (STZ) induced diabetic rats. SD rats (n = 75) were randomly divided into 5 groups (normal control, diabetic control, 3 different dose LESWT treated diabetic groups). Diabetic rats were induced by intra-peritoneal injection of STZ (60 mg/kg) and rats with fasting blood glucose ≥ 300 mg/dL were selected as diabetic models. Twelve weeks later, different doses of LESWT (100, 200 and 300 shocks each time) treatment on penises were used to treat ED (7.33 MPa, 2 shocks/s) three times a week for two weeks. The erectile function was evaluated by intracavernous pressure (ICP) after 1 week washout period. Then the penises were harvested for histological study. The results showed LESWT could significantly improve the erectile function of diabetic rats, increase smooth muscle and endothelial contents, up-regulate the expression of α-SMA, vWF, nNOS and VEGF, and down- regulate the expression of RAGE in corpus cavernosum. The therapeutic effect might relate to treatment dose positively, and the maximal therapeutic effect was noted in the LESWT300 group. Consequently, 300 shocks each time might be the ideal LESWT dose for diabetic ED treatment.
Keywords: erectile dysfunction; diabetes mellitus; low energy shock wave therapy; corpus cavernosum
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Liu, J.; Zhou, F.; Li, G.-Y.; Wang, L.; Li, H.-X.; Bai, G.-Y.; Guan, R.-L.; Xu, Y.-D.; Gao, Z.-Z.; Tian, W.-J.; Xin, Z.-C. Evaluation of the Effect of Different Doses of Low Energy Shock Wave Therapy on the Erectile Function of Streptozotocin (STZ)-Induced Diabetic Rats. Int. J. Mol. Sci. 2013, 14, 10661-10673.
Liu J, Zhou F, Li G-Y, Wang L, Li H-X, Bai G-Y, Guan R-L, Xu Y-D, Gao Z-Z, Tian W-J, Xin Z-C. Evaluation of the Effect of Different Doses of Low Energy Shock Wave Therapy on the Erectile Function of Streptozotocin (STZ)-Induced Diabetic Rats. International Journal of Molecular Sciences. 2013; 14(5):10661-10673.
Liu, Jing; Zhou, Feng; Li, Guang-Yong; Wang, Lin; Li, Hui-Xi; Bai, Guang-Yi; Guan, Rui-Li; Xu, Yong-De; Gao, Ze-Zhu; Tian, Wen-Jie; Xin, Zhong-Cheng. 2013. "Evaluation of the Effect of Different Doses of Low Energy Shock Wave Therapy on the Erectile Function of Streptozotocin (STZ)-Induced Diabetic Rats." Int. J. Mol. Sci. 14, no. 5: 10661-10673.