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TrkB Receptor Signalling: Implications in Neurodegenerative, Psychiatric and Proliferative Disorders
Australian School of Advanced Medicine, Macquarie University, F10A, 2 Technology Place, North Ryde, Sydney, NSW 2109, Australia
Centre of Excellence for Alzheimer's Disease Research & Care, School of Medical Sciences, Edith Cowan University, Joondalup, WA 6027, Australia
Save Sight Institute, Sydney University, Sydney, NSW 2000, Australia
* Author to whom correspondence should be addressed.
Received: 27 March 2013; in revised form: 27 April 2013 / Accepted: 28 April 2013 / Published: 13 May 2013
Abstract: The Trk family of receptors play a wide variety of roles in physiological and disease processes in both neuronal and non-neuronal tissues. Amongst these the TrkB receptor in particular has attracted major attention due to its critical role in signalling for brain derived neurotrophic factor (BDNF), neurotrophin-3 (NT3) and neurotrophin-4 (NT4). TrkB signalling is indispensable for the survival, development and synaptic plasticity of several subtypes of neurons in the nervous system. Substantial evidence has emerged over the last decade about the involvement of aberrant TrkB signalling and its compromise in various neuropsychiatric and degenerative conditions. Unusual changes in TrkB signalling pathway have also been observed and implicated in a range of cancers. Variations in TrkB pathway have been observed in obesity and hyperphagia related disorders as well. Both BDNF and TrkB have been shown to play critical roles in the survival of retinal ganglion cells in the retina. The ability to specifically modulate TrkB signalling can be critical in various pathological scenarios associated with this pathway. In this review, we discuss the mechanisms underlying TrkB signalling, disease implications and explore plausible ameliorative or preventive approaches.
Keywords: neurotrophins; neurodegenerative disorders; psychiatric disorders; cancer; retina; glaucoma; TrkB receptor; BDNF; Shp2 phosphatase
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MDPI and ACS Style
Gupta, V.K.; You, Y.; Gupta, V.B.; Klistorner, A.; Graham, S.L. TrkB Receptor Signalling: Implications in Neurodegenerative, Psychiatric and Proliferative Disorders. Int. J. Mol. Sci. 2013, 14, 10122-10142.
Gupta VK, You Y, Gupta VB, Klistorner A, Graham SL. TrkB Receptor Signalling: Implications in Neurodegenerative, Psychiatric and Proliferative Disorders. International Journal of Molecular Sciences. 2013; 14(5):10122-10142.
Gupta, Vivek K.; You, Yuyi; Gupta, Veer B.; Klistorner, Alexander; Graham, Stuart L. 2013. "TrkB Receptor Signalling: Implications in Neurodegenerative, Psychiatric and Proliferative Disorders." Int. J. Mol. Sci. 14, no. 5: 10122-10142.