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Int. J. Mol. Sci. 2013, 14(5), 10143-10161; doi:10.3390/ijms140510143

MAPKs and Signal Transduction in the Control of Gastrointestinal Epithelial Cell Proliferation and Differentiation

Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of São Paulo, SP 05508-000, Brazil
* Author to whom correspondence should be addressed.
Received: 26 February 2013 / Revised: 19 April 2013 / Accepted: 22 April 2013 / Published: 13 May 2013
(This article belongs to the Special Issue Signalling Molecules and Signal Transduction in Cells)
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Mitogen-activated protein kinase (MAPK) pathways are activated by several stimuli and transduce the signal inside cells, generating diverse responses including cell proliferation, differentiation, migration and apoptosis. Each MAPK cascade comprises a series of molecules, and regulation takes place at different levels. They communicate with each other and with additional pathways, creating a signaling network that is important for cell fate determination. In this review, we focus on ERK, JNK, p38 and ERK5, the major MAPKs, and their interactions with PI3K-Akt, TGFβ/Smad and Wnt/β-catenin pathways. More importantly, we describe how MAPKs regulate cell proliferation and differentiation in the rapidly renewing epithelia that lines the gastrointestinal tract and, finally, we highlight the recent findings on nutritional aspects that affect MAPK transduction cascades.
Keywords: MAPK; cell cycle; differentiation MAPK; cell cycle; differentiation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Osaki, L.H.; Gama, P. MAPKs and Signal Transduction in the Control of Gastrointestinal Epithelial Cell Proliferation and Differentiation. Int. J. Mol. Sci. 2013, 14, 10143-10161.

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