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Int. J. Mol. Sci. 2013, 14(5), 10042-10062; doi:10.3390/ijms140510042

Genome-Wide Gene Expression Profiles in Antioxidant Pathways and Their Potential Sex Differences and Connections to Vitamin C in Mice

1
Department of Orthopedic Surgery and BME-Campbell Clinic, University of Tennessee Health Science Center, Memphis, TN 38163, USA
2
Mudanjiang Medical College, Mudanjiang 157001, Heilongjiang, China
3
The First Hospital of Qiqihaer City, 30 Gongyuan Road, Longsha District, Qiqihaer 161005, Heilongjiang, China
4
Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
5
Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China
*
Author to whom correspondence should be addressed.
Received: 10 January 2013 / Revised: 7 April 2013 / Accepted: 28 April 2013 / Published: 10 May 2013
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Abstract

Vitamin C (VC) is well known as an antioxidant in humans, primates and guinea pigs. Studies have suggested gender differences in VC requirements in humans, and gender differences in oxidant injury vulnerability in early life may represent a biological mechanism contributing to gender disparity in later life. Using spontaneous bone fracture (sfx) mice, which lack the gene for L-Gulonolactone oxidase (Gulo), we studied the potential sex difference in expression profiles of oxidative genes at the whole-genome level. Then, we analyzed data of gene expressions in a mouse population of recombinant inbred (RI) strains originally derived by crossing C57BL/6J (B6) and DBA/2J (D2) mice. Our data indicated that there were sex differences in the regulation of pre- and pro-oxidative genes in sfx mice. The associations of expression levels among Gulo, its partner genes and oxidative genes in the BXD (B6 × D2) RI strains showed a sex difference. Transcriptome mapping suggests that Gulo was regulated differently between female and male mice in BXD RI strains. Our study indicates the importance of investigating sex differences in Gulo and its oxidative function by using available mouse models.
Keywords: L-Gulonolactone oxidase; mouse; oxidative; vitamin C; sex L-Gulonolactone oxidase; mouse; oxidative; vitamin C; sex
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Jiao, Y.; Chen, H.; Yan, J.; Wang, L.; Huang, Y.; Liu, X.; Williams, R.W.; Lu, L.; Wang, Y.; Gu, W. Genome-Wide Gene Expression Profiles in Antioxidant Pathways and Their Potential Sex Differences and Connections to Vitamin C in Mice. Int. J. Mol. Sci. 2013, 14, 10042-10062.

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Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
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