Next Article in Journal
Characterization, Purification of Poncirin from Edible Citrus Ougan (Citrus reticulate cv. Suavissima) and Its Growth Inhibitory Effect on Human Gastric Cancer Cells SGC-7901
Next Article in Special Issue
Melatonin-Based Therapeutics for Neuroprotection in Stroke
Previous Article in Journal
Single Nucleotide Polymorphisms in the Leptin-a Gene and Associations with Growth Traits in the Orange-Spotted Grouper (Epinephelus coioides)
Previous Article in Special Issue
Homology Models of Melatonin Receptors: Challenges and Recent Advances
Article Menu

Export Article

Open AccessReview
Int. J. Mol. Sci. 2013, 14(4), 8638-8683; doi:10.3390/ijms14048638

Melatonin: Buffering the Immune System

1
Institute of Biomedicine of Seville (IBiS) and Department of Medical Biochemistry and Molecular Biology, Virgen del Rocío University Hospital/CSIC/University of Seville, 41013 Sevilla, Spain
2
Institute of Biomedicine of Seville (IBiS) and Department of Clinical Biochemistry, Virgen del Rocío University Hospital/CSIC/University of Seville, 41013 Sevilla, Spain
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 1 March 2013 / Revised: 6 April 2013 / Accepted: 7 April 2013 / Published: 22 April 2013
(This article belongs to the Special Issue Advances in the Research of Melatonin)
View Full-Text   |   Download PDF [567 KB, uploaded 19 June 2014]   |  

Abstract

Melatonin modulates a wide range of physiological functions with pleiotropic effects on the immune system. Despite the large number of reports implicating melatonin as an immunomodulatory compound, it still remains unclear how melatonin regulates immunity. While some authors argue that melatonin is an immunostimulant, many studies have also described anti-inflammatory properties. The data reviewed in this paper support the idea of melatonin as an immune buffer, acting as a stimulant under basal or immunosuppressive conditions or as an anti-inflammatory compound in the presence of exacerbated immune responses, such as acute inflammation. The clinical relevance of the multiple functions of melatonin under different immune conditions, such as infection, autoimmunity, vaccination and immunosenescence, is also reviewed.
Keywords: melatonin; pineal; immune system; cytokines; inflammation; infection; autoimmunity; vaccination; immunosenescence melatonin; pineal; immune system; cytokines; inflammation; infection; autoimmunity; vaccination; immunosenescence
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Carrillo-Vico, A.; Lardone, P.J.; Álvarez-Sánchez, N.; Rodríguez-Rodríguez, A.; Guerrero, J.M. Melatonin: Buffering the Immune System. Int. J. Mol. Sci. 2013, 14, 8638-8683.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top