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Melatonin-Based Therapeutics for Neuroprotection in Stroke
AbstractThe present review paper supports the approach to deliver melatonin and to target melatonin receptors for neuroprotection in stroke. We discuss laboratory evidence demonstrating neuroprotective effects of exogenous melatonin treatment and transplantation of melatonin-secreting cells in stroke. In addition, we describe a novel mechanism of action underlying the therapeutic benefits of stem cell therapy in stroke, implicating the role of melatonin receptors. As we envision the clinical entry of melatonin-based therapeutics, we discuss translational experiments that warrant consideration to reveal an optimal melatonin treatment strategy that is safe and effective for human application.
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Shinozuka, K.; Staples, M.; Borlongan, C.V. Melatonin-Based Therapeutics for Neuroprotection in Stroke. Int. J. Mol. Sci. 2013, 14, 8924-8947.View more citation formats
Shinozuka K, Staples M, Borlongan CV. Melatonin-Based Therapeutics for Neuroprotection in Stroke. International Journal of Molecular Sciences. 2013; 14(5):8924-8947.Chicago/Turabian Style
Shinozuka, Kazutaka; Staples, Meaghan; Borlongan, Cesar V. 2013. "Melatonin-Based Therapeutics for Neuroprotection in Stroke." Int. J. Mol. Sci. 14, no. 5: 8924-8947.
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