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Int. J. Mol. Sci. 2013, 14(5), 8924-8947; doi:10.3390/ijms14058924
Review

Melatonin-Based Therapeutics for Neuroprotection in Stroke

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Received: 8 March 2013; in revised form: 10 April 2013 / Accepted: 11 April 2013 / Published: 25 April 2013
(This article belongs to the Special Issue Advances in the Research of Melatonin)
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Abstract: The present review paper supports the approach to deliver melatonin and to target melatonin receptors for neuroprotection in stroke. We discuss laboratory evidence demonstrating neuroprotective effects of exogenous melatonin treatment and transplantation of melatonin-secreting cells in stroke. In addition, we describe a novel mechanism of action underlying the therapeutic benefits of stem cell therapy in stroke, implicating the role of melatonin receptors. As we envision the clinical entry of melatonin-based therapeutics, we discuss translational experiments that warrant consideration to reveal an optimal melatonin treatment strategy that is safe and effective for human application.
Keywords: oxidative stress; stroke; neuroprotection; cerebral ischemia; melatonin oxidative stress; stroke; neuroprotection; cerebral ischemia; melatonin
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Shinozuka, K.; Staples, M.; Borlongan, C.V. Melatonin-Based Therapeutics for Neuroprotection in Stroke. Int. J. Mol. Sci. 2013, 14, 8924-8947.

AMA Style

Shinozuka K, Staples M, Borlongan CV. Melatonin-Based Therapeutics for Neuroprotection in Stroke. International Journal of Molecular Sciences. 2013; 14(5):8924-8947.

Chicago/Turabian Style

Shinozuka, Kazutaka; Staples, Meaghan; Borlongan, Cesar V. 2013. "Melatonin-Based Therapeutics for Neuroprotection in Stroke." Int. J. Mol. Sci. 14, no. 5: 8924-8947.



Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert