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Melatonin-Based Therapeutics for Neuroprotection in Stroke
Center of Excellence for Aging & Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, 12901 Bruce B. Downs Blvd., Tampa, FL 33612, USA
* Author to whom correspondence should be addressed.
Received: 8 March 2013; in revised form: 10 April 2013 / Accepted: 11 April 2013 / Published: 25 April 2013
Abstract: The present review paper supports the approach to deliver melatonin and to target melatonin receptors for neuroprotection in stroke. We discuss laboratory evidence demonstrating neuroprotective effects of exogenous melatonin treatment and transplantation of melatonin-secreting cells in stroke. In addition, we describe a novel mechanism of action underlying the therapeutic benefits of stem cell therapy in stroke, implicating the role of melatonin receptors. As we envision the clinical entry of melatonin-based therapeutics, we discuss translational experiments that warrant consideration to reveal an optimal melatonin treatment strategy that is safe and effective for human application.
Keywords: oxidative stress; stroke; neuroprotection; cerebral ischemia; melatonin
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MDPI and ACS Style
Shinozuka, K.; Staples, M.; Borlongan, C.V. Melatonin-Based Therapeutics for Neuroprotection in Stroke. Int. J. Mol. Sci. 2013, 14, 8924-8947.
Shinozuka K, Staples M, Borlongan CV. Melatonin-Based Therapeutics for Neuroprotection in Stroke. International Journal of Molecular Sciences. 2013; 14(5):8924-8947.
Shinozuka, Kazutaka; Staples, Meaghan; Borlongan, Cesar V. 2013. "Melatonin-Based Therapeutics for Neuroprotection in Stroke." Int. J. Mol. Sci. 14, no. 5: 8924-8947.