Next Article in Journal
Proteins Involved in Distinct Phases of Cold Hardening Process in Frost Resistant Winter Barley (Hordeum vulgare L.) cv Luxor
Next Article in Special Issue
Homology Models of Melatonin Receptors: Challenges and Recent Advances
Previous Article in Journal
Specific siRNA Targeting Receptor for Advanced Glycation End Products (RAGE) Decreases Proliferation in Human Breast Cancer Cell Lines
Previous Article in Special Issue
Melatonin Inhibits GnRH-1, GnRH-3 and GnRH Receptor Expression in the Brain of the European Sea Bass, Dicentrarchus labrax
Int. J. Mol. Sci. 2013, 14(4), 7979-7999; doi:10.3390/ijms14047979
Review

Influence of Melatonin on the Immune System of Fish: A Review

1,* , 1
, 2
 and 1
Received: 15 January 2013; in revised form: 26 March 2013 / Accepted: 27 March 2013 / Published: 11 April 2013
(This article belongs to the Special Issue Advances in the Research of Melatonin)
View Full-Text   |   Download PDF [218 KB, uploaded 19 June 2014]
Abstract: Endocrine-immune system interactions have been widely demonstrated in mammals, whereas in fish, these relationships remain unclear. Of the organs that constitute the endocrine system, the pineal gland and its secretory product melatonin act in the synchronization of daily and seasonal rhythms in most vertebrates, including fish. Seasonal differences in immunocompetence and disease prevalence have been well documented in humans. Seasonality also strongly influences the life history of fish by controlling the timing of physiological events, such as reproduction, food intake, locomotor activity, and growth performance. Apart from its synchronizing capabilities, the role of melatonin in physiological processes in fish is not thoroughly understood. The purpose of this review is to summarize current studies on the effects of melatonin on the fish immune system. These studies suggest that melatonin represents an important component of fish endocrine-immune system interactions. The elucidation of the defense mechanisms of fish will facilitate the development of health management tools to support the growing finfish aquaculture industry as well as address questions concerning the origins and evolution of the immune system in vertebrates.
Keywords: endocrine-immune system; rhythms; season; melatonin; immunity; fish endocrine-immune system; rhythms; season; melatonin; immunity; fish
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Esteban, M.Á.; Cuesta, A.; Chaves-Pozo, E.; Meseguer, J. Influence of Melatonin on the Immune System of Fish: A Review. Int. J. Mol. Sci. 2013, 14, 7979-7999.

AMA Style

Esteban MÁ, Cuesta A, Chaves-Pozo E, Meseguer J. Influence of Melatonin on the Immune System of Fish: A Review. International Journal of Molecular Sciences. 2013; 14(4):7979-7999.

Chicago/Turabian Style

Esteban, M. Ángeles; Cuesta, Alberto; Chaves-Pozo, Elena; Meseguer, José. 2013. "Influence of Melatonin on the Immune System of Fish: A Review." Int. J. Mol. Sci. 14, no. 4: 7979-7999.


Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert