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The Yin-Yang of DNA Damage Response: Roles in Tumorigenesis and Cellular Senescence
Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang 110001, China
Department of Medical Oncology, The Fourth Affiliated Hospital, China Medical University, Shenyang 110032, China
Section of Molecular Medicine, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
Department of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong
Radiation Medicine Branch, National Cancer Center, Goyang, Gyenggi 410-769, Korea
* Authors to whom correspondence should be addressed.
Received: 16 November 2012; in revised form: 8 January 2013 / Accepted: 9 January 2013 / Published: 25 January 2013
Abstract: Senescent cells are relatively stable, lacking proliferation capacity yet retaining metabolic activity. In contrast, cancer cells are rather invasive and devastating, with uncontrolled proliferative capacity and resistance to cell death signals. Although tumorigenesis and cellular senescence are seemingly opposite pathological events, they are actually driven by a unified mechanism: DNA damage. Integrity of the DNA damage response (DDR) network can impose a tumorigenesis barrier by navigating abnormal cells to cellular senescence. Compromise of DDR, possibly due to the inactivation of DDR components, may prevent cellular senescence but at the expense of tumor formation. Here we provide an overview of the fundamental role of DDR in tumorigenesis and cellular senescence, under the light of the Yin-Yang concept of Chinese philosophy. Emphasis is placed on discussing DDR outcome in the light of in vivo models. This information is critical as it can help make better decisions for clinical treatments of cancer patients.
Keywords: DNA damage response; cell cycle arrest; tumorigenesis; senescence
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Li, X.; Xu, H.; Xu, C.; Lin, M.; Song, X.; Yi, F.; Feng, Y.; Coughlan, K.A.; Cho, W.C.-S.; Kim, S.S.; Cao, L. The Yin-Yang of DNA Damage Response: Roles in Tumorigenesis and Cellular Senescence. Int. J. Mol. Sci. 2013, 14, 2431-2448.
Li X, Xu H, Xu C, Lin M, Song X, Yi F, Feng Y, Coughlan KA, Cho WC-S, Kim SS, Cao L. The Yin-Yang of DNA Damage Response: Roles in Tumorigenesis and Cellular Senescence. International Journal of Molecular Sciences. 2013; 14(2):2431-2448.
Li, Xiaoman; Xu, Hongde; Xu, Chongan; Lin, Meina; Song, Xiaoyu; Yi, Fei; Feng, Yanling; Coughlan, Kathleen A.; Cho, William C.-S.; Kim, Sang S.; Cao, Liu. 2013. "The Yin-Yang of DNA Damage Response: Roles in Tumorigenesis and Cellular Senescence." Int. J. Mol. Sci. 14, no. 2: 2431-2448.