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Parkinson’s Disease: A Complex Interplay of Mitochondrial DNA Alterations and Oxidative Stress
Department of Biology, University of Rome "Tor Vergata", Via della Ricerca Scientifica, 00133 Rome, Italy
Laboratoire de Biologie Moléculaire et Cellulaire du Cancer, Kirchberg Hospital, 9 Rue Edward Steichen, 2540 Luxembourg, Luxembourg
College of Pharmacy, Seoul National University, 599 Gwanak-ro, Gwanak-gu, Seoul 151-742, Korea
* Author to whom correspondence should be addressed.
Received: 5 December 2012; in revised form: 14 January 2013 / Accepted: 21 January 2013 / Published: 24 January 2013
Abstract: Parkinson’s disease (PD) is one of the most common age-related neurodegenerative diseases. This pathology causes a significant loss of dopaminergic neurons in the Substantia Nigra. Several reports have claimed a role of defective nuclear and mitochondrial DNA repair pathways in PD etiology, in particular, of the Base Excision Repair (BER) system. In addition, recent findings, related to PD progression, indicate that oxidative stress pathways involving c-Abl and GST could also be implicated in this pathology. This review focuses on recently described networks most likely involved in an integrated manner in the course of PD.
Keywords: neurodegenerative diseases; Parkinson’s disease (PD); base excision repair (BER); mitochondria; oxidative stress; reactive oxidative species (ROS); reactive nitrogen species (RNS); c-Abl; reduced glutathione (GSH); oxidized glutathione (GSS-)
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MDPI and ACS Style
Ciccone, S.; Maiani, E.; Bellusci, G.; Diederich, M.; Gonfloni, S. Parkinson’s Disease: A Complex Interplay of Mitochondrial DNA Alterations and Oxidative Stress. Int. J. Mol. Sci. 2013, 14, 2388-2409.
Ciccone S, Maiani E, Bellusci G, Diederich M, Gonfloni S. Parkinson’s Disease: A Complex Interplay of Mitochondrial DNA Alterations and Oxidative Stress. International Journal of Molecular Sciences. 2013; 14(2):2388-2409.
Ciccone, Sarah; Maiani, Emiliano; Bellusci, Giovanna; Diederich, Marc; Gonfloni, Stefania. 2013. "Parkinson’s Disease: A Complex Interplay of Mitochondrial DNA Alterations and Oxidative Stress." Int. J. Mol. Sci. 14, no. 2: 2388-2409.