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Melatonin Anticancer Effects: Review
Di Bella Foundation, Via Guglielmo Marconi 51, Bologna 40122, Italy
Private Laboratory of Physiology, Via Stefano Giovanni Marianini, Modena 41123, Italy
* Author to whom correspondence should be addressed.
Received: 5 December 2012; in revised form: 14 January 2013 / Accepted: 15 January 2013 / Published: 24 January 2013
Abstract: Melatonin (N-acetyl-5-methoxytryptamine, MLT), the main hormone produced by the pineal gland, not only regulates circadian rhythm, but also has antioxidant, anti-ageing and immunomodulatory properties. MLT plays an important role in blood composition, medullary dynamics, platelet genesis, vessel endothelia, and in platelet aggregation, leukocyte formula regulation and hemoglobin synthesis. Its significant atoxic, apoptotic, oncostatic, angiogenetic, differentiating and antiproliferative properties against all solid and liquid tumors have also been documented. Thanks, in fact, to its considerable functional versatility, MLT can exert both direct and indirect anticancer effects in factorial synergy with other differentiating, antiproliferative, immunomodulating and trophic molecules that form part of the anticancer treatment formulated by Luigi Di Bella (Di Bella Method, DBM: somatostatin, retinoids, ascorbic acid, vitamin D3, prolactin inhibitors, chondroitin-sulfate). The interaction between MLT and the DBM molecules counters the multiple processes that characterize the neoplastic phenotype (induction, promotion, progression and/or dissemination, tumoral mutation). All these particular characteristics suggest the use of MLT in oncological diseases.
Keywords: melatonin; apoptosis; angiogenesis; APUD system; Di Bella Method
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MDPI and ACS Style
Di Bella, G.; Mascia, F.; Gualano, L.; Di Bella, L. Melatonin Anticancer Effects: Review. Int. J. Mol. Sci. 2013, 14, 2410-2430.
Di Bella G, Mascia F, Gualano L, Di Bella L. Melatonin Anticancer Effects: Review. International Journal of Molecular Sciences. 2013; 14(2):2410-2430.
Di Bella, Giuseppe; Mascia, Fabrizio; Gualano, Luciano; Di Bella, Luigi. 2013. "Melatonin Anticancer Effects: Review." Int. J. Mol. Sci. 14, no. 2: 2410-2430.