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Maintenance of Genomic Stability in Mouse Embryonic Stem Cells: Relevance in Aging and Disease
Department of Clinical and Biological Sciences, University of Turin, Regione Gonzole 10, 10043 Orbassano, Turin, Italy
* Author to whom correspondence should be addressed.
Received: 13 November 2012; in revised form: 11 January 2013 / Accepted: 12 January 2013 / Published: 28 January 2013
Abstract: Recent studies have shown that mouse embryonic stem cells (mESCs) rely on a distinctive genome caretaking network. In this review, we will discuss how mESCs functionally respond to DNA damage and describe several modifications in mESC DNA damage response, which accommodate dynamic cycling and preservation of genetic information. Subsequently, we will discuss how the transition from mESCs to adult stem/progenitor cells can be involved in the decline of tissue integrity and function in the elderly.
Keywords: embryonic stem cells; genotoxic stress; DNA repair; aging; tumor
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MDPI and ACS Style
Giachino, C.; Orlando, L.; Turinetto, V. Maintenance of Genomic Stability in Mouse Embryonic Stem Cells: Relevance in Aging and Disease. Int. J. Mol. Sci. 2013, 14, 2617-2636.
Giachino C, Orlando L, Turinetto V. Maintenance of Genomic Stability in Mouse Embryonic Stem Cells: Relevance in Aging and Disease. International Journal of Molecular Sciences. 2013; 14(2):2617-2636.
Giachino, Claudia; Orlando, Luca; Turinetto, Valentina. 2013. "Maintenance of Genomic Stability in Mouse Embryonic Stem Cells: Relevance in Aging and Disease." Int. J. Mol. Sci. 14, no. 2: 2617-2636.