Int. J. Mol. Sci. 2013, 14(2), 2449-2483; doi:10.3390/ijms14022449
Article

Comparative in Vivo Assessment of Some Adverse Bioeffects of Equidimensional Gold and Silver Nanoparticles and the Attenuation of Nanosilver’s Effects with a Complex of Innocuous Bioprotectors

Received: 9 November 2012; in revised form: 8 January 2013 / Accepted: 9 January 2013 / Published: 25 January 2013
(This article belongs to the Special Issue Bioactive Nanoparticles 2012)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Stable suspensions of nanogold (NG) and nanosilver (NS) with mean particle diameter 50 and 49 nm, respectively, were prepared by laser ablation of metals in water. To assess rat’s pulmonary phagocytosis response to a single intratracheal instillation of these suspensions, we used optical, transmission electron, and semi-contact atomic force microscopy. NG and NS were also repeatedly injected intraperitoneally into rats at a dose of 10 mg/kg (0.5 mg per mL of deionized water) three times a week, up to 20 injections. A group of rats was thus injected with NS after oral administration of a “bioprotective complex” (BPC) comprised of pectin, multivitamins, some amino acids, calcium, selenium, and omega-3 PUFA. After the termination of the injections, many functional and biochemical indices and histopathological features of the spleen, kidneys and liver were evaluated for signs of toxicity, and accumulation of NG or NS in these organs was measured. From the same rats, we obtained cell suspensions of different tissues for performing the RAPD test. It was demonstrated that, although both nanometals were adversely bioactive in all respects considered in this study, NS was more noxious as compared with NG, and that the BPC tested by us attenuated both the toxicity and genotoxicity of NS.
Keywords: nanosilver; nanogold; bronchoalveolar lavage; subchronic toxicity; genotoxicity; bioprotectors
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MDPI and ACS Style

Katsnelson, B.A.; Privalova, L.I.; Gurvich, V.B.; Makeyev, O.H.; Shur, V.Y.; Beikin, Y.B.; Sutunkova, M.P.; Kireyeva, E.P.; Minigalieva, I.A.; Loginova, N.V.; Vasilyeva, M.S.; Korotkov, A.V.; Shuman, E.A.; Vlasova, L.A.; Shishkina, E.V.; Tyurnina, A.E.; Kozin, R.V.; Valamina, I.E.; Pichugova, S.V.; Tulakina, L.G. Comparative in Vivo Assessment of Some Adverse Bioeffects of Equidimensional Gold and Silver Nanoparticles and the Attenuation of Nanosilver’s Effects with a Complex of Innocuous Bioprotectors. Int. J. Mol. Sci. 2013, 14, 2449-2483.

AMA Style

Katsnelson BA, Privalova LI, Gurvich VB, Makeyev OH, Shur VY, Beikin YB, Sutunkova MP, Kireyeva EP, Minigalieva IA, Loginova NV, Vasilyeva MS, Korotkov AV, Shuman EA, Vlasova LA, Shishkina EV, Tyurnina AE, Kozin RV, Valamina IE, Pichugova SV, Tulakina LG. Comparative in Vivo Assessment of Some Adverse Bioeffects of Equidimensional Gold and Silver Nanoparticles and the Attenuation of Nanosilver’s Effects with a Complex of Innocuous Bioprotectors. International Journal of Molecular Sciences. 2013; 14(2):2449-2483.

Chicago/Turabian Style

Katsnelson, Boris A.; Privalova, Larisa I.; Gurvich, Vladimir B.; Makeyev, Oleg H.; Shur, Vladimir Y.; Beikin, Yakov B.; Sutunkova, Marina P.; Kireyeva, Ekaterina P.; Minigalieva, Ilzira A.; Loginova, Nadezhda V.; Vasilyeva, Marina S.; Korotkov, Artem V.; Shuman, Eugene A.; Vlasova, Larisa A.; Shishkina, Ekaterina V.; Tyurnina, Anastasia E.; Kozin, Roman V.; Valamina, Irene E.; Pichugova, Svetlana V.; Tulakina, Ludmila G. 2013. "Comparative in Vivo Assessment of Some Adverse Bioeffects of Equidimensional Gold and Silver Nanoparticles and the Attenuation of Nanosilver’s Effects with a Complex of Innocuous Bioprotectors." Int. J. Mol. Sci. 14, no. 2: 2449-2483.

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