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Int. J. Mol. Sci. 2013, 14(12), 23639-23653; doi:10.3390/ijms141223639

Sustained Release of Prindopril Erbumine from Its Chitosan-Coated Magnetic Nanoparticles for Biomedical Applications

1
Materials Synthesis and Characterization Laboratory (MSCL), Institute of Advanced Technology (ITMA), Universiti Putra Malaysia, Selangor 43400, Malaysia
2
Vaccines and Immunotherapeutics Laboratory (IBS), Universiti Putra Malaysia, Selangor 43400, Malaysia
3
Department of Physics, Faculty of Science, Universiti Putra Malaysia, Selangor 43400, Malaysia
4
Chemical Pathology Unit, Department of pathology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor 43400, Malaysia
*
Author to whom correspondence should be addressed.
Received: 21 August 2013 / Revised: 27 October 2013 / Accepted: 1 November 2013 / Published: 3 December 2013
(This article belongs to the Special Issue Magnetic Nanoparticles 2013)
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Abstract

The preparation of magnetic nanoparticles coated with chitosan-prindopril erbumine was accomplished and confirmed by X-ray diffraction, TEM, magnetic measurements, thermal analysis and infrared spectroscopic studies. X-ray diffraction and TEM results demonstrated that the magnetic nanoparticles were pure iron oxide phase, having a spherical shape with a mean diameter of 6 nm, compared to 15 nm after coating with chitosan-prindopril erbumine (FCPE). Fourier transform infrared spectroscopy study shows that the coating of iron oxide nanoparticles takes place due to the presence of some bands that were emerging after the coating process, which belong to the prindopril erbumine (PE). The thermal stability of the PE in an FCPE nanocomposite was remarkably enhanced. The release study showed that around 89% of PE could be released within about 93 hours by a phosphate buffer solution at pH 7.4, which was found to be of sustained manner governed by first order kinetic. Compared to the control (untreated), cell viability study in 3T3 cells at 72 h post exposure to both the nanoparticles and the pure drug was found to be sustained above 80% using different doses.
Keywords: superparamagnetic nanoparticles; chitosan; prindopril erbumine; drug delivery superparamagnetic nanoparticles; chitosan; prindopril erbumine; drug delivery
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Dorniani, D.; Hussein, M.Z.B.; Kura, A.U.; Fakurazi, S.; Shaari, A.H.; Ahmad, Z. Sustained Release of Prindopril Erbumine from Its Chitosan-Coated Magnetic Nanoparticles for Biomedical Applications. Int. J. Mol. Sci. 2013, 14, 23639-23653.

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