Int. J. Mol. Sci. 2013, 14(12), 23654-23671; doi:10.3390/ijms141223654
Article

Antitumor Mechanisms of Amino Acid Hydroxyurea Derivatives in the Metastatic Colon Cancer Model

1email, 1email, 2email, 1email, 1email, 3email, 3email, 4email, 5email, 6email and 6,* email
Received: 18 September 2013; in revised form: 15 October 2013 / Accepted: 31 October 2013 / Published: 4 December 2013
(This article belongs to the Section Molecular Pathology)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: The paper presents a detailed study of the biological effects of two amino acid hydroxyurea derivatives that showed selective antiproliferative effects in vitro on the growth of human tumor cell line SW620. Tested compounds induced cell cycle perturbations and apoptosis. Proteins were identified by proteomics analyses using two-dimensional gel electrophoresis coupled to mass spectrometry, which provided a complete insight into the most probable mechanism of action on the protein level. Molecular targets for tested compounds were analyzed by cheminformatics tools. Zinc-dependent histone deacetylases were identified as potential targets responsible for the observed antiproliferative effect.
Keywords: colorectal cancer; amino acid hydroxyurea derivatives; HDAC inhibition; anti-proliferative effect
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MDPI and ACS Style

Šaban, N.; Stepanić, V.; Vučinić, S.; Horvatić, A.; Cindrić, M.; Perković, I.; Zorc, B.; Oršolić, N.; Mintas, M.; Pavelić, K.; Pavelić, S.K. Antitumor Mechanisms of Amino Acid Hydroxyurea Derivatives in the Metastatic Colon Cancer Model. Int. J. Mol. Sci. 2013, 14, 23654-23671.

AMA Style

Šaban N, Stepanić V, Vučinić S, Horvatić A, Cindrić M, Perković I, Zorc B, Oršolić N, Mintas M, Pavelić K, Pavelić SK. Antitumor Mechanisms of Amino Acid Hydroxyurea Derivatives in the Metastatic Colon Cancer Model. International Journal of Molecular Sciences. 2013; 14(12):23654-23671.

Chicago/Turabian Style

Šaban, Nina; Stepanić, Višnja; Vučinić, Srđan; Horvatić, Anita; Cindrić, Mario; Perković, Ivana; Zorc, Branka; Oršolić, Nada; Mintas, Mladen; Pavelić, Krešimir; Pavelić, Sandra K. 2013. "Antitumor Mechanisms of Amino Acid Hydroxyurea Derivatives in the Metastatic Colon Cancer Model." Int. J. Mol. Sci. 14, no. 12: 23654-23671.

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