Next Article in Journal
The Role of Photolabile Dermal Nitric Oxide Derivates in Ultraviolet Radiation (UVR)-Induced Cell Death
Next Article in Special Issue
Early Exercise Protects against Cerebral Ischemic Injury through Inhibiting Neuron Apoptosis in Cortex in Rats
Previous Article in Journal
A Potential Daidzein Derivative Enhances Cytotoxicity of Epirubicin on Human Colon Adenocarcinoma Caco-2 Cells
Previous Article in Special Issue
1-Benzyl-2-Phenylbenzimidazole (BPB), a Benzimidazole Derivative, Induces Cell Apoptosis in Human Chondrosarcoma through Intrinsic and Extrinsic Pathways
Int. J. Mol. Sci. 2013, 14(1), 177-190; doi:10.3390/ijms14010177
Review

Changes in Translational Control after Pro-Apoptotic Stress

1
, 1
, 1
 and 1,2,*
Received: 30 July 2012; in revised form: 6 November 2012 / Accepted: 10 December 2012 / Published: 21 December 2012
(This article belongs to the collection Programmed Cell Death and Apoptosis)
View Full-Text   |   Download PDF [273 KB, uploaded 19 June 2014]   |   Browse Figures
Abstract: In stressed cells, a general decrease in the rate of protein synthesis occurs due to modifications in the activity of translation initiation factors. Compelling data now indicate that these changes also permit a selective post-transcriptional expression of proteins necessary for either cell survival or completion of apoptosis when cells are exposed to severe or prolonged stress. In this review, we summarize the modifications that inhibit the activity of the main canonical translation initiation factors, and the data explaining how certain mRNAs encoding proteins involved in either cell survival or apoptosis can be selectively translated.
Keywords: translation initiation; eIF2; eIF4F; 4E-BPs; apoptosis; uORF; IRES translation initiation; eIF2; eIF4F; 4E-BPs; apoptosis; uORF; IRES
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Lasfargues, C.; Martineau, Y.; Bousquet, C.; Pyronnet, S. Changes in Translational Control after Pro-Apoptotic Stress. Int. J. Mol. Sci. 2013, 14, 177-190.

AMA Style

Lasfargues C, Martineau Y, Bousquet C, Pyronnet S. Changes in Translational Control after Pro-Apoptotic Stress. International Journal of Molecular Sciences. 2013; 14(1):177-190.

Chicago/Turabian Style

Lasfargues, Charline; Martineau, Yvan; Bousquet, Corinne; Pyronnet, Stéphane. 2013. "Changes in Translational Control after Pro-Apoptotic Stress." Int. J. Mol. Sci. 14, no. 1: 177-190.


Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert