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Int. J. Mol. Sci. 2013, 14(1), 177-190; doi:10.3390/ijms14010177
Review

Changes in Translational Control after Pro-Apoptotic Stress

1
, 1
, 1
 and 1,2,*
1 INSERM UMR-1037 Université de Toulouse, Centre de Recherche en Cancérologie de Toulouse (CRCT) and Laboratoire d'Excellence Toulouse Cancer, TOUCAN, Toulouse 31432, France 2 Centre Hospitalier de Toulouse, Pôle Digestif, Toulouse 31432, France
* Author to whom correspondence should be addressed.
Received: 30 July 2012 / Revised: 6 November 2012 / Accepted: 10 December 2012 / Published: 21 December 2012
(This article belongs to the collection Programmed Cell Death and Apoptosis)
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Abstract

In stressed cells, a general decrease in the rate of protein synthesis occurs due to modifications in the activity of translation initiation factors. Compelling data now indicate that these changes also permit a selective post-transcriptional expression of proteins necessary for either cell survival or completion of apoptosis when cells are exposed to severe or prolonged stress. In this review, we summarize the modifications that inhibit the activity of the main canonical translation initiation factors, and the data explaining how certain mRNAs encoding proteins involved in either cell survival or apoptosis can be selectively translated.
Keywords: translation initiation; eIF2; eIF4F; 4E-BPs; apoptosis; uORF; IRES translation initiation; eIF2; eIF4F; 4E-BPs; apoptosis; uORF; IRES
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Lasfargues, C.; Martineau, Y.; Bousquet, C.; Pyronnet, S. Changes in Translational Control after Pro-Apoptotic Stress. Int. J. Mol. Sci. 2013, 14, 177-190.

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