Int. J. Mol. Sci. 2013, 14(1), 191-204; doi:10.3390/ijms14010191
Review

The Role of Photolabile Dermal Nitric Oxide Derivates in Ultraviolet Radiation (UVR)-Induced Cell Death

1,* email and 2email
Received: 26 October 2012; in revised form: 11 December 2012 / Accepted: 12 December 2012 / Published: 21 December 2012
(This article belongs to the Special Issue UV-Induced Cell Death 2012)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Human skin is exposed to solar ultraviolet radiation comprising UVB (280–315 nm) and UVA (315–400 nm) on a daily basis. Within the last two decades, the molecular and cellular response to UVA/UVB and the possible effects on human health have been investigated extensively. It is generally accepted that the mutagenic and carcinogenic properties of UVB is due to the direct interaction with DNA. On the other hand, by interaction with non-DNA chromophores as endogenous photosensitizers, UVA induces formation of reactive oxygen species (ROS), which play a pivotal role as mediators of UVA-induced injuries in human skin. This review gives a short overview about relevant findings concerning the molecular mechanisms underlying UVA/UVB-induced cell death. Furthermore, we will highlight the potential role of cutaneous antioxidants and photolabile nitric oxide derivates (NODs) in skin physiology. UVA-induced decomposition of the NODs, like nitrite, leads not only to non-enzymatic formation of nitric oxide (NO), but also to toxic reactive nitrogen species (RNS), like peroxynitrite. Whereas under antioxidative conditions the generation of protective amounts of NO is favored, under oxidative conditions, less injurious reactive nitrogen species are generated, which may enhance UVA-induced cell death.
Keywords: UVA; nitrite; nitric oxide; cell death; lipid peroxidation; apoptosis; necrosis; antioxidants
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MDPI and ACS Style

Opländer, C.; Suschek, C.V. The Role of Photolabile Dermal Nitric Oxide Derivates in Ultraviolet Radiation (UVR)-Induced Cell Death. Int. J. Mol. Sci. 2013, 14, 191-204.

AMA Style

Opländer C, Suschek CV. The Role of Photolabile Dermal Nitric Oxide Derivates in Ultraviolet Radiation (UVR)-Induced Cell Death. International Journal of Molecular Sciences. 2013; 14(1):191-204.

Chicago/Turabian Style

Opländer, Christian; Suschek, Christoph V. 2013. "The Role of Photolabile Dermal Nitric Oxide Derivates in Ultraviolet Radiation (UVR)-Induced Cell Death." Int. J. Mol. Sci. 14, no. 1: 191-204.


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