Int. J. Mol. Sci. 2012, 13(12), 16971-16985; doi:10.3390/ijms131216971
Article

Increased Insulin Sensitivity and Distorted Mitochondrial Adaptations during Muscle Unloading

1,2email, 1,2email, 3email, 1,2email and 2,* email
Received: 23 September 2012; in revised form: 27 November 2012 / Accepted: 29 November 2012 / Published: 11 December 2012
(This article belongs to the Special Issue Advances in Free Radicals in Biology and Medicine)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: We aimed to further investigate mitochondrial adaptations to muscle disuse and the consequent metabolic disorders. Male rats were submitted to hindlimb unloading (HU) for three weeks. Interestingly, HU increased insulin sensitivity index (ISI) and decreased blood level of triglyceride and insulin. In skeletal muscle, HU decreased expression of pyruvate dehydrogenase kinase 4 (PDK4) and its protein level in mitochondria. HU decreased mtDNA content and mitochondrial biogenesis biomarkers. Dynamin-related protein (Drp1) in mitochondria and Mfn2 mRNA level were decreased significantly by HU. Our findings provide more extensive insight into mitochondrial adaptations to muscle disuse, involving the shift of fuel utilization towards glucose, the decreased mitochondrial biogenesis and the distorted mitochondrial dynamics.
Keywords: mitochondrial; insulin sensitivity; pyruvate dehydrogenase kinase 4; hindlimb unloading; skeletal muscle
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MDPI and ACS Style

Qi, Z.; Zhang, Y.; Guo, W.; Ji, L.; Ding, S. Increased Insulin Sensitivity and Distorted Mitochondrial Adaptations during Muscle Unloading. Int. J. Mol. Sci. 2012, 13, 16971-16985.

AMA Style

Qi Z, Zhang Y, Guo W, Ji L, Ding S. Increased Insulin Sensitivity and Distorted Mitochondrial Adaptations during Muscle Unloading. International Journal of Molecular Sciences. 2012; 13(12):16971-16985.

Chicago/Turabian Style

Qi, Zhengtang; Zhang, Yuan; Guo, Wei; Ji, Liu; Ding, Shuzhe. 2012. "Increased Insulin Sensitivity and Distorted Mitochondrial Adaptations during Muscle Unloading." Int. J. Mol. Sci. 13, no. 12: 16971-16985.

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