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• Percário, S
• Moreira, DR.
• Gomes, BA. Q.
• Ferreira, ME. S.
• Gonçalves, ACarolina M.
• Laurindo, PS. O. C.
• Vilhena, TC.
• Dolabela, MF.
• Green, MD.
• [+] on Google Scholar
• Percário, S
• Moreira, DR.
• Gomes, BA. Q.
• Ferreira, ME. S.
• Gonçalves, ACarolina M.
• Laurindo, PS. O. C.
• Vilhena, TC.
• Dolabela, MF.
• Green, MD.
• [+] on PubMed
• Percário, S
• Moreira, DR.
• Gomes, BA. Q.
• Ferreira, ME. S.
• Gonçalves, ACarolina M.
• Laurindo, PS. O. C.
• Vilhena, TC.
• Dolabela, MF.
• Green, MD.

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Int. J. Mol. Sci. 2012, 13(12), 16346-16372; doi:10.3390/ijms131216346

Review

Oxidative Stress in Malaria

Sandro Percário ^1,* , Danilo R. Moreira ¹ , Bruno A. Q. Gomes ¹ , Michelli E. S. Ferreira ¹ , Ana Carolina M. Gonçalves ¹ , Paula S. O. C. Laurindo ¹ , Thyago C. Vilhena ¹ , Maria F. Dolabela ²  and Michael D. Green ³

¹ Oxidative Stress Research Laboratory, Institute of Biological Sciences, Federal University of Para (LAPEO/ICB/UFPA) Av. Augusto Correa, 1, Guama, Belem, Para 66075-110, Brazil ² Pharmacy Faculty, Institute of Health Sciences, Federal University of Para. Av. Augusto Correa, 1, Guama, Belem, Para 66075-110, Brazil ³ US Centers for Disease Control and Prevention, 1600 Clifton Road NE, mailstop G49, Atlanta, GA 30329, USA

* Author to whom correspondence should be addressed.

Received: 17 October 2012; in revised form: 8 November 2012 / Accepted: 23 November 2012 / Published: 3 December 2012

(This article belongs to the Special Issue Advances in Free Radicals in Biology and Medicine)

Download PDF Full-Text [256 KB, uploaded 3 December 2012 10:33 CET]

Abstract: Malaria is a significant public health problem in more than 100 countries and causes an estimated 200 million new infections every year. Despite the significant effort to eradicate this dangerous disease, lack of complete knowledge of its physiopathology compromises the success in this enterprise. In this paper we review oxidative stress mechanisms involved in the disease and discuss the potential benefits of antioxidant supplementation as an adjuvant antimalarial strategy.

Keywords: oxidative stress; malaria; free radicals; antioxidants; Agaricus sylvaticus; nitric oxide

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