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Oxidative Stress in Malaria
Oxidative Stress Research Laboratory, Institute of Biological Sciences, Federal University of Para (LAPEO/ICB/UFPA) Av. Augusto Correa, 1, Guama, Belem, Para 66075-110, Brazil
Pharmacy Faculty, Institute of Health Sciences, Federal University of Para. Av. Augusto Correa, 1, Guama, Belem, Para 66075-110, Brazil
US Centers for Disease Control and Prevention, 1600 Clifton Road NE, mailstop G49, Atlanta, GA 30329, USA
* Author to whom correspondence should be addressed.
Received: 17 October 2012; in revised form: 8 November 2012 / Accepted: 23 November 2012 / Published: 3 December 2012
Abstract: Malaria is a significant public health problem in more than 100 countries and causes an estimated 200 million new infections every year. Despite the significant effort to eradicate this dangerous disease, lack of complete knowledge of its physiopathology compromises the success in this enterprise. In this paper we review oxidative stress mechanisms involved in the disease and discuss the potential benefits of antioxidant supplementation as an adjuvant antimalarial strategy.
Keywords: oxidative stress; malaria; free radicals; antioxidants; Agaricus sylvaticus; nitric oxide
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Percário, S.; Moreira, D.R.; Gomes, B.A.Q.; Ferreira, M.E.S.; Gonçalves, A.C.M.; Laurindo, P.S.O.C.; Vilhena, T.C.; Dolabela, M.F.; Green, M.D. Oxidative Stress in Malaria. Int. J. Mol. Sci. 2012, 13, 16346-16372.
Percário S, Moreira DR, Gomes BAQ, Ferreira MES, Gonçalves ACM, Laurindo PSOC, Vilhena TC, Dolabela MF, Green MD. Oxidative Stress in Malaria. International Journal of Molecular Sciences. 2012; 13(12):16346-16372.
Percário, Sandro; Moreira, Danilo R.; Gomes, Bruno A.Q.; Ferreira, Michelli E.S.; Gonçalves, Ana C.M.; Laurindo, Paula S.O.C.; Vilhena, Thyago C.; Dolabela, Maria F.; Green, Michael D. 2012. "Oxidative Stress in Malaria." Int. J. Mol. Sci. 13, no. 12: 16346-16372.