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Effects of Sesamin on Streptozotocin (STZ)-Induced NIT-1 Pancreatic β-Cell Damage
School of Biology and food engineering, Hefei University of Technology, Hefei 230009, China
* Author to whom correspondence should be addressed.
Received: 14 November 2012; in revised form: 4 December 2012 / Accepted: 5 December 2012 / Published: 11 December 2012
Abstract: The protective effect of sesamin (SES) from sesame meal on NIT-1 pancreatic β-cells damaged by streptozotocin (STZ) in vitro was investigated. The cell viability, insulin secretion, the activity of superoxide dismutase(SOD), glutathione peroxidase (GSHpx) and the content of reduced glutathione (GSH) increased significantly when incubated with SES (400, 200 µg mL−1). The content of malondialdehyde (MDA), nitric oxide (NO) production, and the activity of NO synthase (NOS), inducible NOS (iNOS), decreased significantly when incubated with SES. The destructive changes of NIT-1 cells were ameliorated when treated with SES under microscopic observation. These data suggested that SES had obvious protective effect on NIT-1 pancreatic β-cells damaged by STZ, which might be related to its effects of decreasing levels of β-cell-destroying factors such as oxidative stress and NO synthesis.
Keywords: sesamin (SES); NIT-1 pancreatic β-cell; streptozotocin (STZ); protective effect
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MDPI and ACS Style
Lei, H.; Han, J.; Wang, Q.; Guo, S.; Sun, H.; Zhang, X. Effects of Sesamin on Streptozotocin (STZ)-Induced NIT-1 Pancreatic β-Cell Damage. Int. J. Mol. Sci. 2012, 13, 16961-16970.
Lei H, Han J, Wang Q, Guo S, Sun H, Zhang X. Effects of Sesamin on Streptozotocin (STZ)-Induced NIT-1 Pancreatic β-Cell Damage. International Journal of Molecular Sciences. 2012; 13(12):16961-16970.
Lei, Hong; Han, Juncheng; Wang, Qin; Guo, Shuzhen; Sun, Hanju; Zhang, Xiaoxiang. 2012. "Effects of Sesamin on Streptozotocin (STZ)-Induced NIT-1 Pancreatic β-Cell Damage." Int. J. Mol. Sci. 13, no. 12: 16961-16970.