Int. J. Mol. Sci. 2012, 13(12), 16961-16970; doi:10.3390/ijms131216961
Article

Effects of Sesamin on Streptozotocin (STZ)-Induced NIT-1 Pancreatic β-Cell Damage

Hong Lei* email, Juncheng Hanemail, Qin Wangemail, Shuzhen Guoemail, Hanju Sunemail and Xiaoxiang Zhangemail
School of Biology and food engineering, Hefei University of Technology, Hefei 230009, China
* Author to whom correspondence should be addressed.
Received: 14 November 2012; in revised form: 4 December 2012 / Accepted: 5 December 2012 / Published: 11 December 2012
(This article belongs to the Section Bioactives and Nutraceuticals)
PDF Full-text Download PDF Full-Text [748 KB, uploaded 11 December 2012 11:00 CET]
Abstract: The protective effect of sesamin (SES) from sesame meal on NIT-1 pancreatic β-cells damaged by streptozotocin (STZ) in vitro was investigated. The cell viability, insulin secretion, the activity of superoxide dismutase(SOD), glutathione peroxidase (GSHpx) and the content of reduced glutathione (GSH) increased significantly when incubated with SES (400, 200 µg mL−1). The content of malondialdehyde (MDA), nitric oxide (NO) production, and the activity of NO synthase (NOS), inducible NOS (iNOS), decreased significantly when incubated with SES. The destructive changes of NIT-1 cells were ameliorated when treated with SES under microscopic observation. These data suggested that SES had obvious protective effect on NIT-1 pancreatic β-cells damaged by STZ, which might be related to its effects of decreasing levels of β-cell-destroying factors such as oxidative stress and NO synthesis.
Keywords: sesamin (SES); NIT-1 pancreatic β-cell; streptozotocin (STZ); protective effect

Article Statistics

Click here to load and display the download statistics.

Cite This Article

MDPI and ACS Style

Lei, H.; Han, J.; Wang, Q.; Guo, S.; Sun, H.; Zhang, X. Effects of Sesamin on Streptozotocin (STZ)-Induced NIT-1 Pancreatic β-Cell Damage. Int. J. Mol. Sci. 2012, 13, 16961-16970.

AMA Style

Lei H, Han J, Wang Q, Guo S, Sun H, Zhang X. Effects of Sesamin on Streptozotocin (STZ)-Induced NIT-1 Pancreatic β-Cell Damage. International Journal of Molecular Sciences. 2012; 13(12):16961-16970.

Chicago/Turabian Style

Lei, Hong; Han, Juncheng; Wang, Qin; Guo, Shuzhen; Sun, Hanju; Zhang, Xiaoxiang. 2012. "Effects of Sesamin on Streptozotocin (STZ)-Induced NIT-1 Pancreatic β-Cell Damage." Int. J. Mol. Sci. 13, no. 12: 16961-16970.

Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert