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MiR-218 Impairs Tumor Growth and Increases Chemo-Sensitivity to Cisplatin in Cervical Cancer
Department of Gynecology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Shanghai 200092, China
Department of Gynecology and Obstetrics, Changhai Hospital, Second Military Medical University, 168 Changhai Road, Shanghai 200433, China
These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 28 August 2012; in revised form: 15 October 2012 / Accepted: 25 October 2012 / Published: 28 November 2012
Abstract: MicroRNAs are noncoding RNA molecules of 18–25 nucleotides that regulate gene expression at the post-transcriptional levels. Recent data revealed that miR-218 played key roles in tumor metastasis. Here, we described the regulation and function of miR-218 in cervical cancer. Overexpression of miR-218 reduced the proliferation of the human cervical cancer cell line HeLa and induced cell apoptosis through the AKT-mTOR signaling pathway. In addition, it forced expression of miR-218 suppressed tumor growth in the orthotopic mouse model of HeLa cells. Furthermore, miR-218 increased chemosensitivity to cisplatin (CDDP) in vitro. Our results indicated that targeting miR-218 may provide a strategy for blocking the development of cervical cancer.
Keywords: miR-218; cervical cancer; HeLa; cisplatin
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MDPI and ACS Style
Li, J.; Ping, Z.; Ning, H. MiR-218 Impairs Tumor Growth and Increases Chemo-Sensitivity to Cisplatin in Cervical Cancer. Int. J. Mol. Sci. 2012, 13, 16053-16064.
Li J, Ping Z, Ning H. MiR-218 Impairs Tumor Growth and Increases Chemo-Sensitivity to Cisplatin in Cervical Cancer. International Journal of Molecular Sciences. 2012; 13(12):16053-16064.
Li, Jiarui; Ping, Zhang; Ning, Hui. 2012. "MiR-218 Impairs Tumor Growth and Increases Chemo-Sensitivity to Cisplatin in Cervical Cancer." Int. J. Mol. Sci. 13, no. 12: 16053-16064.