Int. J. Mol. Sci. 2012, 13(12), 15767-15783; doi:10.3390/ijms131215767
Review

The Role of Sox Genes in Lung Morphogenesis and Cancer

1,2email, 1email, 2,* email and 1,* email
Received: 25 September 2012; in revised form: 26 October 2012 / Accepted: 14 November 2012 / Published: 26 November 2012
(This article belongs to the Special Issue Advances in Cancer Diagnosis)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: The human lung consists of multiple cell types derived from early embryonic compartments. The morphogenesis of the lung, as well as the injury repair of the adult lung, is tightly controlled by a network of signaling pathways with key transcriptional factors. Lung cancer is the third most cancer-related death in the world, which may be developed due to the failure of regulating the signaling pathways. Sox (sex-determining region Y (Sry) box-containing) family transcriptional factors have emerged as potent modulators in embryonic development, stem cells maintenance, tissue homeostasis, and cancerogenesis in multiple processes. Recent studies demonstrated that the members of the Sox gene family played important roles in the development and maintenance of lung and development of lung cancer. In this context, we summarize our current understanding of the role of Sox family transcriptional factors in the morphogenesis of lung, their oncogenic potential in lung cancer, and their potential impact in the diagnosis, prognosis, and targeted therapy of lung cancer.
Keywords: Sox; lung cancer; lung morphogenesis; transcriptional factors
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MDPI and ACS Style

Zhu, Y.; Li, Y.; Jun Wei, J.W.; Liu, X. The Role of Sox Genes in Lung Morphogenesis and Cancer. Int. J. Mol. Sci. 2012, 13, 15767-15783.

AMA Style

Zhu Y, Li Y, Jun Wei JW, Liu X. The Role of Sox Genes in Lung Morphogenesis and Cancer. International Journal of Molecular Sciences. 2012; 13(12):15767-15783.

Chicago/Turabian Style

Zhu, Yongzhao; Li, Yong; Jun Wei, Jun Wei; Liu, Xiaoming. 2012. "The Role of Sox Genes in Lung Morphogenesis and Cancer." Int. J. Mol. Sci. 13, no. 12: 15767-15783.

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