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The Role of Sox Genes in Lung Morphogenesis and Cancer
AbstractThe human lung consists of multiple cell types derived from early embryonic compartments. The morphogenesis of the lung, as well as the injury repair of the adult lung, is tightly controlled by a network of signaling pathways with key transcriptional factors. Lung cancer is the third most cancer-related death in the world, which may be developed due to the failure of regulating the signaling pathways. Sox (sex-determining region Y (Sry) box-containing) family transcriptional factors have emerged as potent modulators in embryonic development, stem cells maintenance, tissue homeostasis, and cancerogenesis in multiple processes. Recent studies demonstrated that the members of the Sox gene family played important roles in the development and maintenance of lung and development of lung cancer. In this context, we summarize our current understanding of the role of Sox family transcriptional factors in the morphogenesis of lung, their oncogenic potential in lung cancer, and their potential impact in the diagnosis, prognosis, and targeted therapy of lung cancer.
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Zhu, Y.; Li, Y.; Jun Wei, J.W.; Liu, X. The Role of Sox Genes in Lung Morphogenesis and Cancer. Int. J. Mol. Sci. 2012, 13, 15767-15783.View more citation formats
Zhu Y, Li Y, Jun Wei JW, Liu X. The Role of Sox Genes in Lung Morphogenesis and Cancer. International Journal of Molecular Sciences. 2012; 13(12):15767-15783.Chicago/Turabian Style
Zhu, Yongzhao; Li, Yong; Jun Wei, Jun Wei; Liu, Xiaoming. 2012. "The Role of Sox Genes in Lung Morphogenesis and Cancer." Int. J. Mol. Sci. 13, no. 12: 15767-15783.