Next Article in Journal
Next Article in Special Issue
Previous Article in Journal
Previous Article in Special Issue
Int. J. Mol. Sci. 2012, 13(12), 15767-15783; doi:10.3390/ijms131215767

The Role of Sox Genes in Lung Morphogenesis and Cancer

, 1
, 2,*  and 1,*
Received: 25 September 2012; in revised form: 26 October 2012 / Accepted: 14 November 2012 / Published: 26 November 2012
(This article belongs to the Special Issue Advances in Cancer Diagnosis)
View Full-Text   |   Download PDF [442 KB, uploaded 19 June 2014]   |   Browse Figure
Abstract: The human lung consists of multiple cell types derived from early embryonic compartments. The morphogenesis of the lung, as well as the injury repair of the adult lung, is tightly controlled by a network of signaling pathways with key transcriptional factors. Lung cancer is the third most cancer-related death in the world, which may be developed due to the failure of regulating the signaling pathways. Sox (sex-determining region Y (Sry) box-containing) family transcriptional factors have emerged as potent modulators in embryonic development, stem cells maintenance, tissue homeostasis, and cancerogenesis in multiple processes. Recent studies demonstrated that the members of the Sox gene family played important roles in the development and maintenance of lung and development of lung cancer. In this context, we summarize our current understanding of the role of Sox family transcriptional factors in the morphogenesis of lung, their oncogenic potential in lung cancer, and their potential impact in the diagnosis, prognosis, and targeted therapy of lung cancer.
Keywords: Sox; lung cancer; lung morphogenesis; transcriptional factors Sox; lung cancer; lung morphogenesis; transcriptional factors
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |

MDPI and ACS Style

Zhu, Y.; Li, Y.; Jun Wei, J.W.; Liu, X. The Role of Sox Genes in Lung Morphogenesis and Cancer. Int. J. Mol. Sci. 2012, 13, 15767-15783.

AMA Style

Zhu Y, Li Y, Jun Wei JW, Liu X. The Role of Sox Genes in Lung Morphogenesis and Cancer. International Journal of Molecular Sciences. 2012; 13(12):15767-15783.

Chicago/Turabian Style

Zhu, Yongzhao; Li, Yong; Jun Wei, Jun Wei; Liu, Xiaoming. 2012. "The Role of Sox Genes in Lung Morphogenesis and Cancer." Int. J. Mol. Sci. 13, no. 12: 15767-15783.

Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert