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The Role of Sox Genes in Lung Morphogenesis and Cancer
Key Laboratory of the Ministry of Education for Conservation and Utilization of Special Biological Resources in Western China, College of Life science, Ningxia University, Yinchuan 750021, China
Institute of Stem Cell Research, General Hospital of Ningxia Medical University, Yinchuan 750004, China
* Authors to whom correspondence should be addressed.
Received: 25 September 2012; in revised form: 26 October 2012 / Accepted: 14 November 2012 / Published: 26 November 2012
Abstract: The human lung consists of multiple cell types derived from early embryonic compartments. The morphogenesis of the lung, as well as the injury repair of the adult lung, is tightly controlled by a network of signaling pathways with key transcriptional factors. Lung cancer is the third most cancer-related death in the world, which may be developed due to the failure of regulating the signaling pathways. Sox (sex-determining region Y (Sry) box-containing) family transcriptional factors have emerged as potent modulators in embryonic development, stem cells maintenance, tissue homeostasis, and cancerogenesis in multiple processes. Recent studies demonstrated that the members of the Sox gene family played important roles in the development and maintenance of lung and development of lung cancer. In this context, we summarize our current understanding of the role of Sox family transcriptional factors in the morphogenesis of lung, their oncogenic potential in lung cancer, and their potential impact in the diagnosis, prognosis, and targeted therapy of lung cancer.
Keywords: Sox; lung cancer; lung morphogenesis; transcriptional factors
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MDPI and ACS Style
Zhu, Y.; Li, Y.; Jun Wei, J.W.; Liu, X. The Role of Sox Genes in Lung Morphogenesis and Cancer. Int. J. Mol. Sci. 2012, 13, 15767-15783.
Zhu Y, Li Y, Jun Wei JW, Liu X. The Role of Sox Genes in Lung Morphogenesis and Cancer. International Journal of Molecular Sciences. 2012; 13(12):15767-15783.
Zhu, Yongzhao; Li, Yong; Jun Wei, Jun Wei; Liu, Xiaoming. 2012. "The Role of Sox Genes in Lung Morphogenesis and Cancer." Int. J. Mol. Sci. 13, no. 12: 15767-15783.