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Int. J. Mol. Sci. 2012, 13(12), 15784-15800; doi:10.3390/ijms131215784
Review

Brain Metastases from Colorectal Cancer: Microenvironment and Molecular Mechanisms

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Received: 8 October 2012; in revised form: 5 November 2012 / Accepted: 12 November 2012 / Published: 26 November 2012
(This article belongs to the Special Issue Brain Metastasis)
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Abstract: Colorectal cancer is one of the most common digestive tract malignancies in the world. Owing to the newer and more effective systemic therapies, the life of colorectal cancer patients can be remarkably prolonged, and the incidence of brain metastases is increasing. However, little is known about the underlying mechanisms of brain metastasis from colorectal cancer. Here we review the tumor microenvironment and metastasis associated molecules in brain metastases from colorectal cancer. A further understanding of these mechanisms will help us to propose better strategies for colorectal cancer patients with brain metastasis and improve their life quality.
Keywords: colorectal cancer; brain metastasis; microenvironment colorectal cancer; brain metastasis; microenvironment
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Zang, Y.-W.; Gu, X.-D.; Xiang, J.-B.; Chen, Z.-Y. Brain Metastases from Colorectal Cancer: Microenvironment and Molecular Mechanisms. Int. J. Mol. Sci. 2012, 13, 15784-15800.

AMA Style

Zang Y-W, Gu X-D, Xiang J-B, Chen Z-Y. Brain Metastases from Colorectal Cancer: Microenvironment and Molecular Mechanisms. International Journal of Molecular Sciences. 2012; 13(12):15784-15800.

Chicago/Turabian Style

Zang, Yi-Wen; Gu, Xiao-Dong; Xiang, Jian-Bin; Chen, Zong-You. 2012. "Brain Metastases from Colorectal Cancer: Microenvironment and Molecular Mechanisms." Int. J. Mol. Sci. 13, no. 12: 15784-15800.



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