Int. J. Mol. Sci. 2012, 13(12), 15784-15800; doi:10.3390/ijms131215784
Review

Brain Metastases from Colorectal Cancer: Microenvironment and Molecular Mechanisms

Yi-Wen Zang † email, Xiao-Dong Gu † email, Jian-Bin Xiangemail and Zong-You Chen* email
Department of General Surgery, Huashan Hospital, Fudan University, 12 Middle Wulumiqi Road, Shanghai 200040, China † These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 8 October 2012; in revised form: 5 November 2012 / Accepted: 12 November 2012 / Published: 26 November 2012
(This article belongs to the Special Issue Brain Metastasis)
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Abstract: Colorectal cancer is one of the most common digestive tract malignancies in the world. Owing to the newer and more effective systemic therapies, the life of colorectal cancer patients can be remarkably prolonged, and the incidence of brain metastases is increasing. However, little is known about the underlying mechanisms of brain metastasis from colorectal cancer. Here we review the tumor microenvironment and metastasis associated molecules in brain metastases from colorectal cancer. A further understanding of these mechanisms will help us to propose better strategies for colorectal cancer patients with brain metastasis and improve their life quality.
Keywords: colorectal cancer; brain metastasis; microenvironment

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MDPI and ACS Style

Zang, Y.-W.; Gu, X.-D.; Xiang, J.-B.; Chen, Z.-Y. Brain Metastases from Colorectal Cancer: Microenvironment and Molecular Mechanisms. Int. J. Mol. Sci. 2012, 13, 15784-15800.

AMA Style

Zang Y-W, Gu X-D, Xiang J-B, Chen Z-Y. Brain Metastases from Colorectal Cancer: Microenvironment and Molecular Mechanisms. International Journal of Molecular Sciences. 2012; 13(12):15784-15800.

Chicago/Turabian Style

Zang, Yi-Wen; Gu, Xiao-Dong; Xiang, Jian-Bin; Chen, Zong-You. 2012. "Brain Metastases from Colorectal Cancer: Microenvironment and Molecular Mechanisms." Int. J. Mol. Sci. 13, no. 12: 15784-15800.

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