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RORα, a Potential Tumor Suppressor and Therapeutic Target of Breast Cancer
Markey Cancer Center, University of Kentucky, Lexington, KY 40536, USA
Department of Molecular and Biomedical Pharmacology, University of Kentucky, Lexington, KY 40536, USA
* Author to whom correspondence should be addressed.
Received: 12 October 2012; in revised form: 17 November 2012 / Accepted: 19 November 2012 / Published: 26 November 2012
Abstract: The function of the nuclear receptor (NR) in breast cancer progression has been investigated for decades. The majority of the nuclear receptors have well characterized natural ligands, but a few of them are orphan receptors for which no ligand has been identified. RORα, one member of the retinoid orphan nuclear receptor (ROR) subfamily of orphan receptors, regulates various cellular and pathological activities. RORα is commonly down-regulated and/or hypoactivated in breast cancer compared to normal mammary tissue. Expression of RORα suppresses malignant phenotypes in breast cancer cells, in vitro and in vivo. Activity of RORα can be categorized into the canonical and non-canonical nuclear receptor pathways, which in turn regulate various breast cancer cellular function, including cell proliferation, apoptosis and invasion. This information suggests that RORα is a potent tumor suppressor and a potential therapeutic target for breast cancer.
Keywords: RORα; tumor suppressor; therapeutic target; breast cancer
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Cite This Article
MDPI and ACS Style
Du, J.; Xu, R. RORα, a Potential Tumor Suppressor and Therapeutic Target of Breast Cancer. Int. J. Mol. Sci. 2012, 13, 15755-15766.
Du J, Xu R. RORα, a Potential Tumor Suppressor and Therapeutic Target of Breast Cancer. International Journal of Molecular Sciences. 2012; 13(12):15755-15766.
Du, Jun; Xu, Ren. 2012. "RORα, a Potential Tumor Suppressor and Therapeutic Target of Breast Cancer." Int. J. Mol. Sci. 13, no. 12: 15755-15766.