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Int. J. Mol. Sci. 2012, 13(12), 15755-15766; doi:10.3390/ijms131215755

RORα, a Potential Tumor Suppressor and Therapeutic Target of Breast Cancer

1 Markey Cancer Center, University of Kentucky, Lexington, KY 40536, USA 2 Department of Molecular and Biomedical Pharmacology, University of Kentucky, Lexington, KY 40536, USA
* Author to whom correspondence should be addressed.
Received: 12 October 2012 / Revised: 17 November 2012 / Accepted: 19 November 2012 / Published: 26 November 2012
(This article belongs to the Special Issue Signalling Molecules and Signal Transduction in Cells)
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The function of the nuclear receptor (NR) in breast cancer progression has been investigated for decades. The majority of the nuclear receptors have well characterized natural ligands, but a few of them are orphan receptors for which no ligand has been identified. RORα, one member of the retinoid orphan nuclear receptor (ROR) subfamily of orphan receptors, regulates various cellular and pathological activities. RORα is commonly down-regulated and/or hypoactivated in breast cancer compared to normal mammary tissue. Expression of RORα suppresses malignant phenotypes in breast cancer cells, in vitro and in vivo. Activity of RORα can be categorized into the canonical and non-canonical nuclear receptor pathways, which in turn regulate various breast cancer cellular function, including cell proliferation, apoptosis and invasion. This information suggests that RORα is a potent tumor suppressor and a potential therapeutic target for breast cancer.
Keywords: RORα; tumor suppressor; therapeutic target; breast cancer RORα; tumor suppressor; therapeutic target; breast cancer
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Du, J.; Xu, R. RORα, a Potential Tumor Suppressor and Therapeutic Target of Breast Cancer. Int. J. Mol. Sci. 2012, 13, 15755-15766.

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